Reduction-Activatable Fluorogenic Nanobody for Targeted and Low-Background Bioimaging.
Sign Up to like & getrecommendations! Published in 2023 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c04132
Abstract: Environment-sensitive fluorogenic antibodies enable target-specific bioimaging with reduced unspecific background signal and improved spatiotemporal resolution. However, current strategies for the construction of fluorogenic antibodies are hard to handle due to challenges that lie in the… read more here.
Keywords: nanobody targeted; activatable fluorogenic; reduction; fluorogenic nanobody ... See more keywords
A Targeted, Low-Throughput Compound Screen in a Drosophila Model of Neurofibromatosis Type 1 Identifies Simvastatin and BMS-204352 as Potential Therapies for Autism Spectrum Disorder (ASD)
Sign Up to like & getrecommendations! Published in 2022 at "eNeuro"
DOI: 10.1523/eneuro.0461-22.2023
Abstract: Abstract Autism spectrum disorder (ASD) is a common neurodevelopmental condition for which there are no pharmacological therapies that effectively target its core symptomatology. Animal models of syndromic forms of ASD, such as neurofibromatosis type 1,… read more here.
Keywords: autism spectrum; neurofibromatosis type; spectrum disorder; disorder asd ... See more keywords
Oxidative stress induced by berberine-based mitochondria-targeted low temperature photothermal therapy
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2023.1114434
Abstract: Introduction: Mitochondria-targeted low-temperature photothermal therapy (LPTT) is a promising strategy that could maximize anticancer effects and overcome tumor thermal resistance. However, the successful synthesis of mitochondria-targeted nanodrug delivery system for LPTT still faces diverse challenges,… read more here.
Keywords: photothermal therapy; low temperature; temperature photothermal; therapy ... See more keywords