Analytical considerations for (un)-targeted metabolomic studies with special focus on forensic applications.
Sign Up to like & getrecommendations! Published in 2019 at "Drug testing and analysis"
DOI: 10.1002/dta.2540
Abstract: Over the past few years, the interest in metabolomics has increased in various fields including forensic toxicology. Forensic analysis typically requires a high degree of accuracy, which is often a problem in metabolomics applications. We… read more here.
Keywords: targeted metabolomic; metabolomic studies; analytical considerations; considerations targeted ... See more keywords
Identification of Novel Diagnostic Biomarkers in Breast Cancer Using Targeted Metabolomic Profiling.
Sign Up to like & getrecommendations! Published in 2020 at "Clinical breast cancer"
DOI: 10.1016/j.clbc.2020.09.006
Abstract: INTRODUCTION Breast cancer (BC) is the most common cancer in women, with a high disease burden, especially in the advanced disease stages. Our study investigated the metabolomic profile of breast cancer patients' serum with the… read more here.
Keywords: targeted metabolomic; diagnostic biomarkers; breast cancer; sensitivity specificity ... See more keywords
A Comprehensive Targeted Metabolomic Assay for Urine Analysis.
Sign Up to like & getrecommendations! Published in 2020 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.0c01682
Abstract: Among all the human biological fluids used for disease biomarker discovery or clinical chemistry, urine stands out. It can be col-lected easily and non-invasively, it is readily available in large volumes, it is typically free… read more here.
Keywords: targeted metabolomic; analysis; chemistry; metabolomic assay ... See more keywords
Proteomic and Targeted Metabolomic Studies on a Silkworm Model of Parkinson's Disease.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.2c00149
Abstract: Parkinson's disease (PD) is a chronic and progressive movement disorder that is characterized by the loss of dopaminergic neurons in the brain. Animal models of PD have become very popular in the past two decades… read more here.
Keywords: silkworm model; parkinson disease; proteomic targeted; model ... See more keywords
Targeted metabolomic profiling of cerebrospinal fluid from patients with progressive multifocal leukoencephalopathy
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0242321
Abstract: Progressive multifocal leukoencephalopathy (PML), caused by JC polyomavirus, is a demyelinating disease of the central nervous system that primarily affects oligodendrocytes. It can cause significant morbidity and mortality. An early diagnosis is of high relevance… read more here.
Keywords: multifocal leukoencephalopathy; cerebrospinal fluid; targeted metabolomic; progressive multifocal ... See more keywords
Toward Reproducible Results from Targeted Metabolomic Studies: Perspectives for Data Pre-processing and a Basis for Analytic Pipeline Development.
Sign Up to like & getrecommendations! Published in 2018 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026618666180711144323
Abstract: Contemporary metabolomics experiments generate a rich array of complex high-dimensional data. Consequently, there have been concurrent efforts to develop methodological standards and analytical workflows to streamline the generation of meaningful biochemical and clinical inferences from… read more here.
Keywords: reproducible results; pipeline; targeted metabolomic; toward reproducible ... See more keywords
Nontargeted and Targeted Metabolomic Profiling Reveals Novel Metabolite Biomarkers of Incident Diabetes in African Americans
Sign Up to like & getrecommendations! Published in 2022 at "Diabetes"
DOI: 10.2337/db22-0033
Abstract: Nontargeted metabolomics methods have increased potential to identify new disease biomarkers, but assessments of the additive information provided in large human cohorts by these less biased techniques are limited. To diversify our knowledge of diabetes-associated… read more here.
Keywords: reveals novel; nontargeted targeted; profiling reveals; african americans ... See more keywords
Dynamic Changes in Non-Volatile Components during Steamed Green Tea Manufacturing Based on Widely Targeted Metabolomic Analysis
Sign Up to like & getrecommendations! Published in 2023 at "Foods"
DOI: 10.3390/foods12071551
Abstract: Steamed green tea has unique characteristics that differ from other green teas. However, the alteration patterns of non-volatile metabolites during steamed green tea processing are not fully understood. In this study, a widely targeted metabolomic… read more here.
Keywords: steamed green; green tea; targeted metabolomic; widely targeted ... See more keywords
Untargeted and Targeted Metabolomic Profiling of Australian Indigenous Fruits
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DOI: 10.3390/metabo10030114
Abstract: Selected Australian native fruits such as Davidson’s plum, finger lime and native pepperberry have been reported to demonstrate potent antioxidant activity. However, comprehensive metabolite profiling of these fruits is limited, therefore the compounds responsible are… read more here.
Keywords: metabolomic profiling; antioxidant activity; targeted metabolomic; indigenous fruits ... See more keywords
Development of a Novel Targeted Metabolomic LC-QqQ-MS Method in Allergic Inflammation
Sign Up to like & getrecommendations! Published in 2022 at "Metabolites"
DOI: 10.3390/metabo12070592
Abstract: The transition from mild to severe allergic phenotypes is still poorly understood and there is an urgent need of incorporating new therapies, accompanied by personalized diagnosis approaches. This work presents the development of a novel… read more here.
Keywords: methodology; development novel; allergic inflammation; targeted metabolomic ... See more keywords
In Vivo Targeted Metabolomic Profiling of Prostanit, a Novel Anti-PAD NO-Donating Alprostadil-Based Drug
Sign Up to like & getrecommendations! Published in 2020 at "Molecules"
DOI: 10.3390/molecules25245896
Abstract: Prostanit is a novel drug developed for the treatment of peripheral arterial diseases. It consists of a prostaglandin E1 (PGE1) moiety with two nitric oxide (NO) donor fragments, which provide a combined vasodilation effect on… read more here.
Keywords: metabolomic profiling; targeted metabolomic; prostanit novel; drug ... See more keywords