Spleen‐Targeted mRNA Nanoparticles for Modulating B Cell Hyperactivation in Rheumatoid Arthritis Therapy
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202417101
Abstract: Messenger RNA (mRNA)‐based therapies have emerged as a revolutionary strategy for treating various diseases. In autoimmune diseases like rheumatoid arthritis (RA), targeted mRNA delivery provides a potential intervention to modulate immune responses. However, achieving specific… read more here.
Keywords: riib; spleen targeted; targeted mrna; rheumatoid arthritis ... See more keywords
Spleen-Targeted mRNA Vaccine Doped with Manganese Adjuvant for Robust Anticancer Immunity In Vivo.
Sign Up to like & getrecommendations! Published in 2024 at "ACS nano"
DOI: 10.1021/acsnano.4c09902
Abstract: The successful application of mRNA vaccines in preventing and treating infectious diseases highlights their potential as therapeutic vaccines for cancer treatment. However, unlike infectious diseases, effective antitumor therapy, particularly for solid tumors, necessitates the activation… read more here.
Keywords: mrna vaccine; immunity; spleen targeted; targeted mrna ... See more keywords
RGD peptide-based lipids for targeted mRNA delivery and gene editing applications
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra02771b
Abstract: mRNA therapeutics are promising platforms for protein replacement therapies and gene editing technologies. When delivered via non-viral gene delivery systems, such as lipid nanoparticles (LNPs), mRNA therapeutics are easy to produce and show low toxicity… read more here.
Keywords: mrna delivery; rgd; gene editing; targeted mrna ... See more keywords
Non-viral mRNA delivery to the lungs.
Sign Up to like & getrecommendations! Published in 2025 at "Biomaterials science"
DOI: 10.1039/d5bm00322a
Abstract: The rapid advancement of mRNA therapeutics, exemplified by COVID-19 vaccines, underscores the transformative potential of non-viral delivery systems. However, achieving efficient and targeted mRNA delivery to the lungs remains a critical challenge due to biological… read more here.
Keywords: delivery; non viral; targeted mrna; mrna delivery ... See more keywords