Rational engineering of a human GFP-like protein scaffold for humanized targeted nanomedicines.
Sign Up to like & getrecommendations! Published in 2021 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2021.06.001
Abstract: Green fluorescent protein (GFP) is a widely used scaffold for protein-based targeted nanomedicines because of its high biocompatibility, biological neutrality and outstanding structural stability. However, being immunogenicity a major concern in the development of drug… read more here.
Keywords: protein; protein scaffold; gfp like; like protein ... See more keywords
Abstract 4652: Targeted nanomedicines improve therapeutic indices of RAF and MEK inhibitors
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-4652
Abstract: Potent kinase inhibitors have been developed to treat tumors, but they suppress signaling in normal cells so that their dosing and ability to inhibit the pathway are limited by toxicity, resulting in a narrow therapeutic… read more here.
Keywords: indices raf; therapeutic indices; targeted nanomedicines; improve therapeutic ... See more keywords
Actively Targeted Nanomedicines in Breast Cancer: From Pre-Clinal Investigation to Clinic
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14051198
Abstract: Simple Summary Despite all the efforts and advances made in the treatment of breast cancer, this pathology continues to be one of the main causes of cancer death in women, particularly triple-negative breast cancer (TNBC),… read more here.
Keywords: cancer; breast cancer; investigation; active targeted ... See more keywords