Ovalbumin and Poly(i:c) Encapsulated Dendritic Cell‐Targeted Nanoparticles for Immune Activation in the Small Intestinal Lymphatic System
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202200909
Abstract: Here, antigen and adjuvant encapsulated dendritic cell‐targeted nanoparticles for immune activation in the small intestinal lymphatic system to inhibit melanoma development are described. This strategy is demonstrated using chondroitin sulfate‐coated nanoparticles (OPGMN) grafted with glycocholic… read more here.
Keywords: cell; cell targeted; nanoparticles immune; dendritic cell ... See more keywords
Development of targeted nanoparticles loaded with antiviral drugs for SARS-CoV-2 inhibition
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Medicinal Chemistry"
DOI: 10.1016/j.ejmech.2022.114121
Abstract: Recently, a novel coronavirus, known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has raised global concerns, being the etiological agent of the current pandemic infectious coronavirus disease 2019 (COVID-19). Specific prophylactic treatments like vaccines,… read more here.
Keywords: development; sars cov; inhibition; tnp ... See more keywords
Therapeutic Potential of Targeted Nanoparticles and Perspective on Nanotherapies.
Sign Up to like & getrecommendations! Published in 2020 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.0c00075
Abstract: Engineered nanoparticles (NPs) to specifically deliver payload therapeutics to target cells involved in pathophysiological processes seem to offer a powerful strategy to overcome intrinsic limitations of drugs. In this Viewpoint we disclose the synergistic potential… read more here.
Keywords: targeted nanoparticles; perspective nanotherapies; chemistry; potential targeted ... See more keywords
Ultrasmall targeted nanoparticles with engineered antibody fragments for imaging detection of HER2-overexpressing breast cancer
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06271-5
Abstract: Controlling the biodistribution of nanoparticles upon intravenous injection is the key to achieving target specificity. One of the impediments in nanoparticle-based tumor targeting is the inability to limit the trafficking of nanoparticles to liver and other… read more here.
Keywords: engineered antibody; ultrasmall targeted; targeted nanoparticles; her2 ... See more keywords
Abstract 4641: Improved chemotherapeutic delivery to brain metastases with targeted nanoparticles in preclinical breast cancer brain metastasis models
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-4641
Abstract: Brain metastases present an increasing challenge to long-term survival for HER2-amplified breast cancer patients. While HER2 targeted therapies effectively control systemic metastases, they are largely ineffective against brain metastases due to their inability to cross… read more here.
Keywords: brain metastases; targeted nanoparticles; breast cancer; cancer ... See more keywords
Nucleus-Targeted Nanoparticles Induce Autophagy of Vascular Endothelial Cells in Cervical Spondylosis of Vertebral Artery Type Through PI3K/Akt/mTOR Signaling Pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of biomedical nanotechnology"
DOI: 10.1166/jbn.2022.3257
Abstract: Nanoparticles are characterized by their large surface area per unit and high dispersion, with excellent affinity and adhesion to the tissue, which help them to contact drugs with tissues. However, the relationship between nuclear-targeted nanoparticles… read more here.
Keywords: akt mtor; pi3k akt; nuclear targeted; targeted nanoparticles ... See more keywords
Tumor Targeted Nanoparticles Improve Therapeutic Index of BCL2 and MCL1 dual inhibition.
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood.2020008017
Abstract: Cancer and normal cells utilize multiple anti-apoptotic BCL2 proteins to prevent cell death. Therapeutic targeting of multiple BCL2 family proteins enhances tumor killing, but is also associated with increased systemic toxicity. Here, we demonstrate that… read more here.
Keywords: nanoparticles improve; targeted nanoparticles; improve therapeutic; therapeutic index ... See more keywords
Redox biology of Leishmania and macrophage targeted nanoparticles for therapy.
Sign Up to like & getrecommendations! Published in 2017 at "Nanomedicine"
DOI: 10.2217/nnm-2017-0049
Abstract: Intramacrophage parasite 'Leishmania' has developed various mechanisms for proficient uptake into macrophages and phagosome regulation to avoid macrophage's oxidative burst induced by peroxide, hydroxyl radical, hypochlorous acid and peroxynitrite production. One major barrier for impairing… read more here.
Keywords: targeted nanoparticles; leishmania macrophage; drug; biology ... See more keywords
Targeted nanoparticles modify neutrophil function in vivo
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1003871
Abstract: Neutrophils play critical roles in a broad spectrum of clinical conditions. Accordingly, manipulation of neutrophil function may provide a powerful immunotherapeutic approach. However, due to neutrophils characteristic short half-life and their large population number, this… read more here.
Keywords: neutrophil function; function; vivo; nanoparticles modify ... See more keywords
Novel Poly-(Lactic-Co-Glycolic Acid) Targeted Nanoparticles Conjunct with Antibody for the Enhancement of Antibacterial Activity against Ralstonia solanacearum
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DOI: 10.3390/agronomy11061159
Abstract: Due to the strong pathogenicity of Ralstonia solanacearum, a variety of strategies have been used to develop antibacterial agents; however, antibacterial drugs with targeted effects on R. solanacearum remain lacking. Herein, we present a nanoagent… read more here.
Keywords: solanacearum; plga; activity; antibody ... See more keywords
HER-2-Targeted Nanoparticles for Breast Cancer Diagnosis and Treatment
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DOI: 10.3390/cancers14102424
Abstract: Simple Summary Despite tremendous efforts in finding new therapeutic strategies and promoting screening programs to increase early diagnosis, breast cancer is still a major cause of death in the female worldwide population. Preclinical and clinical… read more here.
Keywords: diagnosis; breast cancer; targeted nanoparticles; nanoparticles breast ... See more keywords