Modular Engineering of Enzyme‐Activatable DNA Nanodevices for Endoplasmic Reticulum‐Targeted Photodynamic Antitumor Therapy
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202503913
Abstract: Endoplasmic reticulum (ER)‐targeted photodynamic therapy (PDT) has garnered wide attention for its potential to improve tumor treatment outcomes. However, achieving spatially selective control over the activation of photosensitizers (PSs) within the ER remains a major… read more here.
Keywords: therapy; endoplasmic reticulum; enzyme activatable; reticulum targeted ... See more keywords
Strategic Design of Aptamer‐Guided Aggregation‐Induced Emission Nanoparticles for Targeted Photodynamic Therapy in Breast Cancer
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202503358
Abstract: Breast cancer (BC), characterized by its heterogeneity and diverse subtypes, necessitates personalized treatment strategies. This study presents MF3Ec‐TBPP nanoparticles (NPs) as a promising approach, integrating an aggregation‐induced emission (AIE)‐based photosensitizer, TBPP, with the MF3Ec aptamer… read more here.
Keywords: breast cancer; aggregation induced; targeted photodynamic; induced emission ... See more keywords
A pH-Activatable nanoparticle for dual-stage precisely mitochondria-targeted photodynamic anticancer therapy.
Sign Up to like & getrecommendations! Published in 2019 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2019.05.030
Abstract: Mitochondria-targeted photodynamic therapy (PDT) has emerged as one of the most efficient antitumor strategies. However, the therapeutic outcome of mitochondria-targeted PDT nanocarriers has been hampered by its poor capability of endosome escape and always-ON mode… read more here.
Keywords: dual stage; mitochondria targeted; targeted photodynamic; activatable nanoparticle ... See more keywords
Synthesis and biological evaluation of phthalocyanine-peptide conjugate for EGFR-targeted photodynamic therapy and bioimaging
Sign Up to like & getrecommendations! Published in 2019 at "Dyes and Pigments"
DOI: 10.1016/j.dyepig.2018.11.055
Abstract: Abstract To improve the biocompatibility and tumor selectivity, we employed an epidermal growth factor receptor (EGFR) binding peptide (namely GE11, with a sequence of Tyr-His-Trp-Tyr-Gly-Tyr-Thr-Pro-Gln-Asn-Val-Ile) as a tumor directing vector for the delivery of zinc(II)… read more here.
Keywords: targeted photodynamic; tyr; therapy bioimaging; peptide ... See more keywords
An integrin-targeting glutathione-activated zinc(II) phthalocyanine for dual targeted photodynamic therapy.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.04.049
Abstract: A zinc(II) phthalocyanine substituted with three 2,4-dinitrobenzenesulfonate (DNBS) groups and a cyclic arginine-glycine-aspartic acid (cRGDfK) moiety was prepared and characterized. With three strongly electron-withdrawing DNBS groups, this compound was fully quenched in terms of fluorescence… read more here.
Keywords: integrin targeting; photodynamic therapy; targeted photodynamic; zinc phthalocyanine ... See more keywords
Enhancing Targeted Photodynamic Therapy: Star-Shaped Glycopolymeric Photosensitizers for Improved Selectivity and Efficacy.
Sign Up to like & getrecommendations! Published in 2024 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.3c01378
Abstract: Targeted photodynamic therapy (PDT) offers advantages over nontargeted approaches, including improved selectivity, efficacy, and reduced side effects. This study developed star-shaped glycopolymeric photosensitizers using porphyrin-based initiators via ATRP. Incorporating a porphyrin core gave the polymers… read more here.
Keywords: improved selectivity; selectivity efficacy; star shaped; shaped glycopolymeric ... See more keywords
Hierarchically Structured Molecularly Imprinted Nanotransducers for Truncated HER2-Targeted Photodynamic Therapy of Therapeutic Antibody-Resistant Breast Cancer.
Sign Up to like & getrecommendations! Published in 2023 at "ACS nano"
DOI: 10.1021/acsnano.3c00148
Abstract: Antibodies have been a mainstream class of therapeutics for clinical treatment of various diseases, especially cancers. However, mutation in cancer cells leads to resistance to therapeutic antibodies, hyperactivity of proliferation of cancer cells, and difficulty… read more here.
Keywords: molecularly imprinted; truncated her2; breast cancer; photodynamic therapy ... See more keywords
The Potential of Nanobody-Targeted Photodynamic Therapy to Trigger Immune Responses
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DOI: 10.3390/cancers12040978
Abstract: Nanobody-targeted photodynamic therapy (NB-PDT) has been recently developed as a more tumor-selective approach rather than conventional photodynamic therapy (PDT). NB-PDT uses nanobodies that bind to tumor cells with high affinity, to selectively deliver a photosensitizer,… read more here.
Keywords: photodynamic therapy; nanobody targeted; targeted photodynamic; pdt ... See more keywords
The Safety and Efficacy of Vascular-Targeted Photodynamic Therapy in Low-Risk Prostate Cancer
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DOI: 10.3390/cancers17040661
Abstract: Simple Summary Nowadays, several techniques have been developed for the management of prostate cancer. Focal therapy represents a choice to limit complications as well as sparing the neurovascular bundles, sphincter, and urethra. The aim of… read more here.
Keywords: efficacy vascular; therapy; prostate cancer; vascular targeted ... See more keywords
EGFR-Targeted Photodynamic Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14020241
Abstract: The epidermal growth factor receptor (EGFR) plays a pivotal role in the proliferation and metastatization of cancer cells. Aberrancies in the expression and activation of EGFR are hallmarks of many human malignancies. As such, EGFR-targeted… read more here.
Keywords: egfr targeted; therapy; photodynamic therapy; targeted photodynamic ... See more keywords