Mitochondria‐Targeted Photoredox Catalysis Activates Pyroptosis for Effective Tumor Therapy
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202417681
Abstract: The development of biocompatible and efficient photocatalytic redox systems to mimic bio‐photoreactors in living cells holds great potential for manipulating intracellular biochemical reaction processes and thus advancing tumor therapy. In this study, a mitochondria‐targeted photoredox… read more here.
Keywords: tumor therapy; mitochondria targeted; tumor; targeted photoredox ... See more keywords
Targeted Photoredox System under a Hypoxic Environment to Evoke Photodynamic Immunotherapy.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.5c01579
Abstract: Conventional oxygen dependent type-II photodynamic therapy (PDT) was significantly constrained by the hypoxic tumor microenvironment. Type-I photosensitizers (PSs) produce oxygen radicals through the electron transfer (ET) pathway and are less oxygen dependent. However, no proven… read more here.
Keywords: targeted photoredox; photoredox system; type; photodynamic immunotherapy ... See more keywords
Targeted photoredox catalysis in cancer cells
Sign Up to like & getrecommendations! Published in 2019 at "Nature Chemistry"
DOI: 10.1038/s41557-019-0328-4
Abstract: Hypoxic tumours are a major problem for cancer photodynamic therapy. Here, we show that photoredox catalysis can provide an oxygen-independent mechanism of action to combat this problem. We have designed a highly oxidative Ir(iii) photocatalyst,… read more here.
Keywords: catalysis cancer; cancer cells; cancer; targeted photoredox ... See more keywords