Targeted Polymeric Nanoparticles Based on Mangiferin for Enhanced Protection of Pancreatic β-Cells and Type 1 Diabetes Mellitus Efficacy.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.1c22964
Abstract: Mangiferin (MGF) is found in many natural plants, such as Rhizoma Anemarrhenae, and has anti-diabetes effects. However, its clinical applications and development are limited by poor solubility and low-concentration enrichment in pancreatic islets. In this… read more here.
Keywords: glp; nanoparticles based; polymeric nanoparticles; mgf ... See more keywords
Folate-targeted polymeric nanoparticles for efficient dual (chemo-photothermal) therapy of oral squamous carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Polymeric Materials and Polymeric Biomaterials"
DOI: 10.1080/00914037.2020.1725756
Abstract: Abstract In this work, the phytochemical anticancer thymoquinone (TQ) and near-infrared plasmonic gold nanorods (AuNRs) were loaded in folate-targeted pegylated poly(d, l-lactide-co-glycolide) (PLGA-PEG-FA) nanocapsules. This polymeric regime exhibited in vitro sustained release kinetics of both… read more here.
Keywords: polymeric nanoparticles; folate targeted; targeted polymeric; chemo photothermal ... See more keywords
Liver-targeted polymeric prodrugs delivered subcutaneously improve tafenoquine therapeutic window for malaria radical cure
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DOI: 10.1126/sciadv.adk4492
Abstract: Approximately 3.3 billion people live with the threat of Plasmodium vivax malaria. Infection can result in liver-localized hypnozoites, which when reactivated cause relapsing malaria. This work demonstrates that an enzyme-cleavable polymeric prodrug of tafenoquine addresses… read more here.
Keywords: therapeutic window; liver targeted; targeted polymeric; tafenoquine ... See more keywords
Targeted Polymeric Micelles System, Designed to Carry a Combined Cargo of L-Asparaginase and Doxorubicin, Shows Vast Improvement in Cytotoxic Efficacy
Sign Up to like & getrecommendations! Published in 2024 at "Polymers"
DOI: 10.3390/polym16152132
Abstract: L-asparaginases (ASP) and Doxorubicin (Dox) are both used in the treatment of leukemia, including in combination. We have attempted to investigate if their combination within the same targeted delivery vehicle can make such therapy more… read more here.
Keywords: system; improvement; combination; dox ... See more keywords