Targeted Polypharmacology: Discovery of a Highly Potent Non-Hydroxamate Dual Matrix Metalloproteinase (MMP)-10/-13 Inhibitor.
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DOI: 10.1021/acs.jmedchem.7b01001
Abstract: Matrix metalloproteinases (MMPs) play a key role in many diseases like cancer, atherosclerosis or arthritis. Interest in MMP inhibition has been revitalized very recently as the knowledge on the underlying network of biological pathways is… read more here.
Keywords: non hydroxamate; targeted polypharmacology; matrix; mmp ... See more keywords