A targeted proteomic assay for the measurement of plasma proteoforms related to human aging phenotypes
Sign Up to like & getrecommendations! Published in 2017 at "PROTEOMICS"
DOI: 10.1002/pmic.201600232
Abstract: Circulating polypeptides and proteins have been implicated in reversing or accelerating aging phenotypes, including growth/differentiation factor 8 (GDF8), GDF11, eotaxin, and oxytocin. These proteoforms, which are defined as the protein products arising from a single… read more here.
Keywords: proteomic assay; plasma; aging phenotypes; targeted proteomic ... See more keywords
Targeted Proteomic Profiling Revealed Roles of Small GTPases during Osteogenic Differentiation.
Sign Up to like & getrecommendations! Published in 2023 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c05781
Abstract: The small GTPase superfamily of proteins are crucial for numerous cellular processes, including early development. The roles of these proteins in osteogenic differentiation, however, remained poorly explored. In this study, we employed a high-throughput targeted… read more here.
Keywords: small gtpases; proteomic profiling; small gtpase; osteogenic differentiation ... See more keywords
Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.2c00225
Abstract: Kinases play important roles in cell signaling, and adenosine monophosphate (AMP) is known to modulate cellular energy homeostasis through AMP-activated protein kinase (AMPK). Here, we explored novel AMP-binding kinases by employing a desthiobiotin-conjugated AMP acyl-phosphate… read more here.
Keywords: binding capacities; amp binding; amp; targeted proteomic ... See more keywords
Targeted proteomic assays for quantitation of proteins identified by proteogenomic analysis of ovarian cancer
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Data"
DOI: 10.1038/sdata.2017.91
Abstract: Mass spectrometry (MS) based targeted proteomic methods such as selected reaction monitoring (SRM) are emerging as a promising tool for verification of candidate proteins in biological and biomedical applications. The Clinical Proteomic Tumor Analysis Consortium… read more here.
Keywords: srm assays; targeted proteomic; analysis; proteomic assays ... See more keywords
Targeted urine proteomics in lupus nephritis – a meta-analysis
Sign Up to like & getrecommendations! Published in 2021 at "Expert Review of Proteomics"
DOI: 10.1080/14789450.2020.1874356
Abstract: ABSTRACT Background Proteomic approaches are central in biomarker discovery. While mass-spectrometry-based techniques are widely used, novel targeted proteomic platforms have enabled the high-throughput detection of low-abundance proteins in an affinity-based manner. Urine has gained growing… read more here.
Keywords: analysis; targeted proteomic; urine proteomics; lupus nephritis ... See more keywords
Abstract 16139: A Targeted Proteomic Approach to Identify Circulating Biomarkers of Heart Failure Risk in Patients With Type 2 Diabetes Mellitus in DECLARE-TIMI 58
Sign Up to like & getrecommendations! Published in 2020 at "Circulation"
DOI: 10.1161/circ.142.suppl_3.16139
Abstract: Background: Patients (pts) with type 2 diabetes mellitus (T2DM) are at increased risk of heart failure (HF); however, the underlying mechanisms by which T2DM contributes to HF are incompletely understood. Hypothesis: We aimed to identify… read more here.
Keywords: declare timi; risk; type diabetes; diabetes mellitus ... See more keywords