Targeted pseudouridylation: An approach for suppressing nonsense mutations in disease genes.
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DOI: 10.2139/ssrn.3988395
Abstract: Nonsense mutations create premature termination codons (PTCs), activating the nonsense-mediated mRNA decay (NMD) pathway to degrade most PTC-containing mRNAs. The undegraded mRNA is translated, but translation terminates at the PTC, leading to no production of… read more here.
Keywords: pseudouridylation approach; pseudouridylation; nonsense mutations; suppression ... See more keywords