Targeted radioimmunotherapy for embryonal tumor with multilayered rosettes
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-019-03139-6
Abstract: PurposeWe explored the use of intraventricular 131I-Omburtamab targeting B7-H3 in patients with ETMR.MethodsPatients were enrolled in an IRB approved, phase 1, 3 + 3 dose escalation trial. Patients with CNS disease expressing the antibody target antigen B7-H3… read more here.
Keywords: 131i omburtamab; omburtamab; targeted radioimmunotherapy; patients etmr ... See more keywords
Possibility of cancer-stem-cell-targeted radioimmunotherapy for acute myelogenous leukemia using 211At-CXCR4 monoclonal antibody
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-63557-9
Abstract: To explore stem-cell-targeted radioimmunotherapy with α-particles in acute myelogenous leukemia (AML), pharmacokinetics and dosimetry of the 211At-labeled anti-C-X-C chemokine receptor type 4 monoclonal antibody (211At-CXCR4 mAb) were conducted using tumor xenografted mice. The biological half-life… read more here.
Keywords: 211at cxcr4; stem cell; cell targeted; targeted radioimmunotherapy ... See more keywords
Macromolecular approach for targeted radioimmunotherapy in non-Hodgkin's lymphoma.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c9cc06603a
Abstract: Polymers are an attractive anchoring platform for the synthesis of radioimmunoconjugates. They enable independent control over the amount of radioisotope loading and antibody attachment, which is pivotal in developing tailorable formulations for personalised medicine. Herein,… read more here.
Keywords: hodgkin lymphoma; macromolecular approach; non hodgkin; targeted radioimmunotherapy ... See more keywords
B7-H3-targeted radioimmunotherapy of human cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Current medicinal chemistry"
DOI: 10.2174/0929867326666190228120908
Abstract: BACKGROUND Targeted radioimmunotherapy (RIT) is an attractive approach to selectively localize therapeutic radionuclides to malignant cells within primary and metastatic tumors while sparing normal tissues from the effects of radiation. Many human malignancies express B7-H3… read more here.
Keywords: human cancer; rit studies; rit; targeted radioimmunotherapy ... See more keywords