Radiation dosimetry of [131I]ICF01012 in rabbits: Application to targeted radionuclide therapy for human melanoma treatment
Sign Up to like & getrecommendations! Published in 2018 at "Medical Physics"
DOI: 10.1002/mp.13165
Abstract: PURPOSE Dosimetry for melanoma-targeted radionuclide therapy (TRT) with [131 I]ICF01012, a melanin ligand, has been previously evaluated in mice bearing melanomas. In this study, activity distribution and dosimetry are performed on healthy rabbits (Fauve de… read more here.
Keywords: melanoma; icf01012; targeted radionuclide; dosimetry ... See more keywords
Voxel-based dosimetry is superior to mean-absorbed dose approach for establishing dose-effect relationship in targeted radionuclide therapy.
Sign Up to like & getrecommendations! Published in 2019 at "Medical physics"
DOI: 10.1002/mp.13851
Abstract: It is becoming evident that patient-individualized dosimetry in targeted radionuclide therapy (TRT) is a must and not a luxury in the era of precision medicine. It's often argued that patient-specific absorbed dose assessment should be… read more here.
Keywords: radionuclide therapy; relationship; dosimetry; absorbed dose ... See more keywords
IgG-Binding Nanobody Capable of Prolonging Nanobody-Based Radiotracer Plasma Half-Life and Enhancing the Efficacy of Tumor-Targeted Radionuclide Therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.2c00209
Abstract: Nanobodies have been developed rapidly as targeted probes for molecular imaging owing to their high affinity, outstanding tissue penetration, and rapid blood clearance. However, the short retention time at the tumor site limits their application… read more here.
Keywords: half life; radionuclide therapy; targeted radionuclide; tumor ... See more keywords
PD-L1-Targeted Radionuclide Therapy Combined with αPD-L1 Antibody Immunotherapy Synergistically Improves the Antitumor Effect.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00281
Abstract: Immune checkpoint blockers (ICBs) targeting programmed death receptor 1 (PD-1) ligand 1 (PD-L1) for immunotherapy have radically reformed oncology. It is of great significance to enhance the response rate of ICB in cancer patients. Here,… read more here.
Keywords: therapy combined; immunotherapy; radionuclide therapy; targeted radionuclide ... See more keywords
Targeted Radionuclide Therapy: A Historical and Personal Review.
Sign Up to like & getrecommendations! Published in 2020 at "Seminars in nuclear medicine"
DOI: 10.1053/j.semnuclmed.2019.07.006
Abstract: This review traces the development of targeted radionuclide therapy (TRT) (the Magic Bullet) from the discovery of radioactivity in nature and the subsequent discovery of artificial radioactivity (the production of radioactive isotopes of stable elements)… read more here.
Keywords: historical personal; targeted radionuclide; review; radionuclide therapy ... See more keywords
Antitumor efficacy of 90Y-NM600 targeted radionuclide therapy and PD-1 blockade is limited by regulatory T cells in murine prostate tumors
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-005060
Abstract: Background Systemic radiation treatments that preferentially irradiate cancer cells over normal tissue, known as targeted radionuclide therapy (TRT), have shown significant potential for treating metastatic prostate cancer. Preclinical studies have demonstrated the ability of external… read more here.
Keywords: 90y nm600; trt; prostate; therapy ... See more keywords
Combining Targeted Radionuclide Therapy and Immune Checkpoint Inhibition for Cancer Treatment
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-21-4332
Abstract: Abstract The development of immunotherapy, in particular immune checkpoint inhibitors (ICI), has revolutionized cancer treatment in the past decades. However, its efficacy is still limited to subgroups of patients with cancer. Therefore, effective treatment combination… read more here.
Keywords: immune checkpoint; radionuclide therapy; targeted radionuclide; treatment ... See more keywords
Targeted Radionuclide Therapy in Patient-Derived Xenografts Using 177Lu-EB-RGD
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-19-1098
Abstract: Currently, most patients with non–small cell lung cancer (NSCLC) are diagnosed in advanced stages with a poor five-year survival rate. Therefore, intensive research aimed at finding novel therapeutic strategies has been ongoing; experimental models that… read more here.
Keywords: 177lu rgd; rgd; pdx; patient derived ... See more keywords
Abstract 2828: Impact of sequencing of immune checkpoint blockade and targeted radionuclide therapy on murine tumor response
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2828
Abstract: Background: Sequencing of immune checkpoint inhibitors (ICI) and external beam radiation therapy (EBRT) for cancer treatment has been studied, but the optimal sequencing has yet to be determined. While some studies have noted therapeutic advantages… read more here.
Keywords: sequencing immune; therapy; 90y 177lu; targeted radionuclide ... See more keywords
Cellular Response to Exponentially Increasing and Decreasing Dose Rates: Implications for Treatment Planning in Targeted Radionuclide Therapy
Sign Up to like & getrecommendations! Published in 2017 at "Radiation Research"
DOI: 10.1667/rr14766.1
Abstract: The treatment of cancer using targeted radionuclide therapy is of interest to nuclear medicine and radiation oncology because of its potential for killing tumor cells while minimizing dose-limiting toxicities to normal tissue. The ionizing radiations… read more here.
Keywords: response; treatment; targeted radionuclide; dose rates ... See more keywords
BIGDOSE: software for 3D personalized targeted radionuclide therapy dosimetry.
Sign Up to like & getrecommendations! Published in 2020 at "Quantitative imaging in medicine and surgery"
DOI: 10.21037/qims.2019.10.09
Abstract: Background Advance 3D quantitative radionuclide imaging techniques boost the accuracy of targeted radionuclide therapy (TRT) dosimetry to voxel level. The goal of this work is to develop a comprehensive 3D dosimetric software, BIGDOSE, with new… read more here.
Keywords: radionuclide therapy; targeted radionuclide; dosimetry; software ... See more keywords