A targeted siRNA‐loaded PDL1‐exosome and functional evaluation against lung cancer
Sign Up to like & getrecommendations! Published in 2022 at "Thoracic Cancer"
DOI: 10.1111/1759-7714.14445
Abstract: As an endocytic nanosicle involved in intercellular communication, an exosome can efficiently deliver drugs from one cell to another and deliver therapeutic short interfering RNA (siRNA) to target cells. This is conducive to gene therapy… read more here.
Keywords: lung cancer; sirna loaded; targeted sirna; cancer targeted ... See more keywords
Abstract LB-B19: Re-sensitizing Pancreatic Cancer, targeted siRNA inhibition of HuR
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-17-lb-b19
Abstract: We have demonstrated that 3DNA nanocarriers can specifically, effectively, and safely deliver siRNA oligos targeted against a pro-survival hub, HuR (the ELAVL1 gene) in an in vivo, pre-clinical model of pancreatic cancer. Pancreatic cancer remains… read more here.
Keywords: targeted sirna; sensitizing pancreatic; hur; pancreatic cancer ... See more keywords
Co-Delivery of Paclitaxel and PLK1-Targeted siRNA Using Aptamer-Functionalized Cationic Liposome for Synergistic Anti-Breast Cancer Effects In Vivo.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of biomedical nanotechnology"
DOI: 10.1166/jbn.2019.2751
Abstract: Cancer cells can develop in several ways to escape from death induced by chemotherapeutic agents, thereby weakening the anti-tumor efficacy of single-target chemotherapy. Therefore, the efficacy of conventional chemotherapy hits a single target in tumor… read more here.
Keywords: plk1 targeted; targeted sirna; sirna using; delivery ... See more keywords
Combined Self-Assembled iRGD Polymersomes for Effective Targeted siRNA Anti-Tumor Therapy
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DOI: 10.2147/ijn.s383862
Abstract: Introduction iRGD is usually used as a motif to modify siRNA-nanodelivery vectors to improve tumor-targeting and penetration. However, most of the modifications are realized by covalent conjugation, which normally requires complex preparation processes possibly with… read more here.
Keywords: irgd; effective targeted; irgd nps; targeted sirna ... See more keywords