Synthesis and evaluation of cationic polymeric micelles as carriers of lumbrokinase for targeted thrombolysis
Sign Up to like & getrecommendations! Published in 2019 at "Asian Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ajps.2018.03.004
Abstract: To achieve targeted thrombolysis, a targeted delivery system of lumbrokinase (LK) was constructed using RGDfk-conjugated hybrid micelles. Based on the specific affinity of RGDfk to glycoprotein complex of GPⅡb/Ⅲa expressed on the surface of membrane… read more here.
Keywords: hybrid micelles; targeted thrombolysis; rgdfk conjugated; rgdfk ... See more keywords
Platelet-targeted thrombolysis for treatment of acute ischemic stroke
Sign Up to like & getrecommendations! Published in 2022 at "Blood Advances"
DOI: 10.1182/bloodadvances.2021006691
Abstract: Key Points • Platelet-targeted thrombolysis with SCE5-scuPA achieved favorable outcomes vs tenecteplase-tPA in 2 mouse models of ischemic stroke.• Thrombolytic strategies that harness activated platelets for drug targeting better suit the platelet-rich nature of stroke-causing… read more here.
Keywords: platelet targeted; targeted thrombolysis; thrombolysis treatment; platelet ... See more keywords