Association between timely targeted treatment and outcomes in patients with metastatic HER2‐overexpressing gastroesophageal adenocarcinoma
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DOI: 10.1002/cncr.34117
Abstract: Timely targeted treatment initiation can be challenging because additional biomarker testing is needed for eligibility. The authors hypothesized that timely targeted treatment improves survival relative to nontimely initiation in metastatic HER2+ gastroesophageal adenocarcinoma (GEA). read more here.
Keywords: gastroesophageal adenocarcinoma; metastatic her2; timely targeted; targeted treatment ... See more keywords
Early Diagnosis and Targeted Treatment Strategy for Improved Therapeutic Outcomes in Alzheimer's Disease.
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DOI: 10.1007/978-3-030-42667-5_8
Abstract: There have been repeated failures of clinical studies in the development of new efficacious treatments for Alzheimer's disease. This may be due to the fact that Alzheimer's disease is a heterogeneous disorder caused by person-to-person… read more here.
Keywords: alzheimer disease; early diagnosis; disease; targeted treatment ... See more keywords
Targeted Treatment of Age-Related Fibromyalgia with Supplemental Coenzyme Q10.
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DOI: 10.1007/978-3-030-55035-6_5
Abstract: Fibromyalgia is a common chronic pain condition of unknown aetiology, although mitochondrial dysfunction, oxidative stress, and inflammation have been implicated in the pathophysiology of this disorder. Treatment generally involves physiotherapy, anticonvulsants, and antidepressant therapy; however,… read more here.
Keywords: coenzyme q10; treatment; targeted treatment; coq10 ... See more keywords
Targeted Treatment of Yaws With Household Contact Tracing: How Much Do We Miss?
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Epidemiology"
DOI: 10.1093/aje/kwx305
Abstract: Abstract Yaws is a disabling bacterial infection found primarily in warm and humid tropical areas. The World Health Organization strategy mandates an initial round of total community treatment (TCT) with single-dose azithromycin followed either by… read more here.
Keywords: asymptomatic infections; contact tracing; treatment; epidemiology ... See more keywords
Genotype‐guided targeted treatment of KRAS‐mutated arteriovenous malformations
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DOI: 10.1111/jdv.18165
Abstract: 1966; 34: 827–857 PMID:5330347. 7 Insee. A Mayotte, pr es d’un habitant sur deux est de nationalit e etrang ere. Montrouge, Paris: Insee Premi ere. 2019;1737 [Internet]. French. https:// www.insee.fr/fr/statistiques/3713016 (last accessed 16 November 2021).… read more here.
Keywords: genotype guided; targeted treatment; kras mutated; guided targeted ... See more keywords
Promoting CRISPRa for Targeted Treatment of Epilepsy
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DOI: 10.1177/1535759720935825
Abstract: In Vivo CRISPRa Decreases Seizures and Rescues Cognitive Deficits in a Rodent Model of Epilepsy Colasante G, Qiu Y, Massimino L, et al. Brain. 2020;143(3):891-905. doi:10.1093/brain/awaa045 Epilepsy is a major health burden, calling for new… read more here.
Keywords: epilepsy; promoting crispra; crispra targeted; crispra ... See more keywords
Molecular biomarkers in gastro-esophageal cancer: recent developments, current trends and future directions
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DOI: 10.1186/s12935-018-0594-z
Abstract: Gastro-esophageal adenocarcinomas (GEA) represent a severe global health burden and despite improvements in the multimodality treatment of these malignancies the prognosis of patients remains poor. HER2 overexpression/amplification has been the first predictive biomarker approved in… read more here.
Keywords: gea; biomarker; treatment; gastro esophageal ... See more keywords
ctDNA analysis in patients with cancer of unknown primary and its value in guiding targeted treatment when combined with predicted cancer types by 90-gene reverse-transcription polymerase chain reaction assay.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2021.39.15_suppl.e18730
Abstract: e18730 Background: No targeted agents except for drugs against NTRK fusion, dMMR/MSI-H or TMB-H are recommended for the treatment of cancer of unknown primary (CUP), despite of the occurrence of multiple actionable mutations identified by… read more here.
Keywords: treatment; cancer; gene; value ... See more keywords
Investigating the impact of NGS data availability on clinical decision-making in brain cancer.
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DOI: 10.1200/jco.2022.40.16_suppl.2032
Abstract: 2032 Background: Next-generation sequencing (NGS) of cancer specimens is a valuable diagnostic tool that can provide detailed information regarding specific somatic genetic alterations within a tumor with potential for targeted treatment. Despite the increasing availability… read more here.
Keywords: clinical decision; targeted treatment; decision making; cancer ... See more keywords
Restoration of fertility potential via targeted treatment approach
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DOI: 10.21037/tau.2017.05.29
Abstract: Dr. O’Flaherty, in his commentary in response to the practice recommendations by Agarwal et al. (1), illustrated two important points that are worth further discussion. Firstly, the author correctly pointed out the low success rate… read more here.
Keywords: potential via; treatment; via targeted; fertility potential ... See more keywords
Targeted Treatment of Relapsed or Refractory Follicular Lymphoma: Focus on the Therapeutic Potential of Mosunetuzumab
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DOI: 10.2147/cmar.s381493
Abstract: Abstract Follicular lymphoma is the most common indolent non-Hodgkin’s lymphoma, and because of the incurable nature of this disorder, new therapies are constantly needed. The recently approved T-cell-dependent bispecific antibody mosunetuzumab showed promising results and… read more here.
Keywords: lymphoma; relapsed refractory; mosunetuzumab; follicular lymphoma ... See more keywords