Exploiting targeted and untargeted approaches for the analysis of bacterial metabolites under altered growth conditions
Sign Up to like & getrecommendations! Published in 2021 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-021-03505-2
Abstract: In the host, pathogenic microorganisms have developed stress responses to cope with constantly changing environments. Stress responses are directly related to changes in several metabolomic pathways, which could hamper microorganisms’ unequivocal identification. We evaluated the… read more here.
Keywords: methodology; untargeted approaches; analysis; targeted untargeted ... See more keywords
Targeted and Untargeted Metabolic Profiling of Wild Grassland Plants identifies Antibiotic and Anthelmintic Compounds Targeting Pathogen Physiology, Metabolism and Reproduction
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-20091-z
Abstract: Plants traditionally used by farmers to manage livestock ailments could reduce reliance on synthetic antibiotics and anthelmintics but in many cases their chemical composition is unknown. As a case study, we analyzed the metabolite profiles… read more here.
Keywords: antibiotic anthelmintic; targeted untargeted; physiology; pathogen physiology ... See more keywords
Clinical applications of quantitative proteomics using targeted and untargeted data-independent acquisition techniques
Sign Up to like & getrecommendations! Published in 2017 at "Expert Review of Proteomics"
DOI: 10.1080/14789450.2017.1322904
Abstract: ABSTRACT Introduction: While selected/multiple-reaction monitoring (SRM or MRM) is considered the gold standard for quantitative protein measurement, emerging data-independent acquisition (DIA) using high-resolution scans have opened a new dimension of high-throughput, comprehensive quantitative proteomics. These… read more here.
Keywords: data independent; targeted untargeted; disease; independent acquisition ... See more keywords
Targeted and untargeted metabolomics provide insight into the consequences of glycine‐N‐methyltransferase deficiency including the novel finding of defective immune function
Sign Up to like & getrecommendations! Published in 2020 at "Physiological Reports"
DOI: 10.14814/phy2.14576
Abstract: Fatty liver disease is increasing along with the prevalence of obesity and type‐2 diabetes. Hepatic fibrosis is a major health complication for which there are no efficacious treatment options available. A better understanding of the… read more here.
Keywords: fibrosis; targeted untargeted; glycine methyltransferase; immune function ... See more keywords
Targeted and untargeted metabolomic approach for GDM diagnosis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.997436
Abstract: Gestational diabetes mellitus (GDM) is a disorder which manifests itself for the first time during pregnancy and is mainly connected with glucose metabolism. It is also known that fatty acid profile changes in erythrocyte membranes… read more here.
Keywords: gdm; fatty acids; oleic acid; targeted untargeted ... See more keywords
Combined Targeted and Untargeted Profiling of HeLa Cells Deficient in Purine De Novo Synthesis
Sign Up to like & getrecommendations! Published in 2022 at "Metabolites"
DOI: 10.3390/metabo12030241
Abstract: Three genetically determined enzyme defects of purine de novo synthesis (PDNS) have been identified so far in humans: adenylosuccinate lyase (ADSL) deficiency, 5-amino-4-imidazole carboxamide-ribosiduria (AICA-ribosiduria), and deficiency in bifunctional enzyme phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase… read more here.
Keywords: hela cells; purine novo; novo synthesis; cells deficient ... See more keywords
Targeted and Untargeted Mass Spectrometry-Based Metabolomics for Chemical Profiling of Three Coffee Species
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27103152
Abstract: While coffee beans have been studied for many years, researchers are showing a growing interest in coffee leaves and by-products, but little information is currently available on coffee species other than Coffea arabica and Coffea… read more here.
Keywords: coffee; coffee species; mass spectrometry; spectrometry based ... See more keywords