LAUSR

Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes.

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1 Published in 2017 at "Cell metabolism"

DOI: 10.1016/j.cmet.2017.03.018

Abstract: In cells experiencing unrelieved endoplasmic reticulum (ER) stress, the ER transmembrane kinase/endoribonuclease (RNase)-IRE1α-endonucleolytically degrades ER-localized mRNAs to promote apoptosis. Here we find that the ABL family of tyrosine kinases rheostatically enhances IRE1α's enzymatic activities, thereby… read more here.

Keywords: ire1 rnase; abl ire1; targeting abl; ire1 signaling ... See more keywords