Targeting the adenosine pathway for cancer immunotherapy.
Sign Up to like & getrecommendations! Published in 2019 at "Seminars in immunology"
DOI: 10.1016/j.smim.2019.101304
Abstract: Suppression of anti-tumor immunity is recognized as a critical step in the development of many types of cancers. Over the past decade, a multitude of immunosuppressive pathways occurring in the tumor microenvironment (TME) have been… read more here.
Keywords: adenosine pathway; cancer immunotherapy; pathway cancer; cancer ... See more keywords
Targeting adenosine in SSc
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Rheumatology"
DOI: 10.1038/s41584-020-0435-z
Abstract: Aberrant activation of adenosinedependent signalling has been implicated in a number of fibrotic diseases, including systemic sclerosis (SSc). The results of a new study indicate that adenosine depletion with recombinant pegylated adenosine deaminase (PEG-ADA) improves… read more here.
Keywords: ssc; ada; treatment; fra2 transgenic ... See more keywords
Targeting adenosine for cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2018 at "Journal for Immunotherapy of Cancer"
DOI: 10.1186/s40425-018-0360-8
Abstract: Immune checkpoint antagonists (CTLA-4 and PD-1/PD-L1) and CAR T-cell therapies generate unparalleled durable responses in several cancers and have firmly established immunotherapy as a new pillar of cancer therapy. To extend the impact of immunotherapy… read more here.
Keywords: immunotherapy; adenosine signaling; adenosine cancer; cancer immunotherapy ... See more keywords
Drugs Targeting the A3 Adenosine Receptor: Human Clinical Study Data
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27123680
Abstract: The A3 adenosine receptor (A3AR) is overexpressed in pathological human cells. Piclidenoson and namodenoson are A3AR agonists with high affinity and selectivity to A3AR. Both induce apoptosis of cancer and inflammatory cells via a molecular… read more here.
Keywords: adenosine receptor; targeting adenosine; study; drugs targeting ... See more keywords