Synthesis and evaluation of 2‐aryl‐1H‐benzo[d]imidazole derivatives as potential microtubule targeting agents
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21909
Abstract: Microtubule targeting agents (MTAs) are the potential drug candidates for anticancer drug discovery. Disrupting the microtubule formation or inhibiting the de‐polymerization process by a synthetic molecule can lead to an excellent anticancer drug candidate. Here,… read more here.
Keywords: microtubule targeting; benzo imidazole; imidazole derivatives; microtubule ... See more keywords
Treatment dynamics of bone‐targeting agents among men with bone metastases from prostate cancer in the United States
Sign Up to like & getrecommendations! Published in 2018 at "Pharmacoepidemiology and Drug Safety"
DOI: 10.1002/pds.4360
Abstract: To examine the dynamics of treatment with 2 bone‐targeting agents (BTAs)—denosumab and zoledronic acid—among men with bone metastases from prostate cancer. read more here.
Keywords: bone targeting; bone metastases; metastases prostate; targeting agents ... See more keywords
Progress of CD47 immune checkpoint blockade agents in anticancer therapy: a hematotoxic perspective
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-021-03815-z
Abstract: CD47, a transmembrane protein, acts as a “do not eat me” signal that is overexpressed in many tumor cell types, thereby forming a signaling axis with its ligand signal regulatory protein alpha (SIRPα) and enabling… read more here.
Keywords: cd47 targeting; cd47; blockade; targeting agents ... See more keywords
Design and synthesis of multifunctional microtubule targeting agents endowed with dual pro-apoptotic and anti-autophagic efficacy.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2022.114274
Abstract: Autophagy is a lysosome dependent cell survival mechanism and is central to the maintenance of organismal homeostasis in both physiological and pathological situations. Targeting autophagy in cancer therapy attracted considerable attention in the past as… read more here.
Keywords: cancer; microtubule targeting; targeting agents; cell ... See more keywords
Dynamic Covalent Template-Guided Screen for Nucleic Acid-Targeting Agents.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01086
Abstract: Trinucleotide repeat diseases such as myotonic dystrophy type 1 (DM1) and Huntington's disease (HD) are caused by expanded DNA repeats that can be used as templates to synthesize their own inhibitors. Because it would be… read more here.
Keywords: nucleic acid; dynamic covalent; chemistry; acid targeting ... See more keywords
The presenting dental status of solid tumours with bone metastases requiring bone-targeting agents - part 4: miscellaneous cancers.
Sign Up to like & getrecommendations! Published in 2022 at "British dental journal"
DOI: 10.1038/s41415-022-3983-6
Abstract: This article discusses relevant information for the dental sector regarding metastatic cancers beyond breast and prostate cancer. Typically, tumour sites such as lung, renal, colorectal, gastrointestinal, thyroid, hepatic and pancreatic cancers are increasingly being referred… read more here.
Keywords: bone; bone metastases; presenting dental; bone targeting ... See more keywords
Methyl-β-cyclodextrin, an actin depolymerizer augments the antiproliferative potential of microtubule-targeting agents
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-43947-4
Abstract: Methyl-β-cyclodextrin (MCD), an established pharmacological excipient, depolymerizes the actin cytoskeleton. In this work, we investigated the effect of MCD-mediated actin depolymerization on various cellular phenotypes including traction force, cell stiffness, focal adhesions, and intracellular drug… read more here.
Keywords: actin; methyl cyclodextrin; targeting agents; cancer ... See more keywords
Abstract 5037: DARPins as powerful targeting agents for radioligand therapeutics
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5037
Abstract: The development of effective radioligand therapeutics (RLTs) is frequently hampered by the lack of high-quality targeting agents that selectively deliver radioactive payloads to the site of disease while sparing healthy tissues. Antibodies can have high… read more here.
Keywords: radioligand therapeutics; affinity; targeting agents; darpin ... See more keywords
Effects of nivolumab alone or combination with molecular targeting agents for recurrent and refractory endometrial cancers with biomarker analyses.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.e17124
Abstract: e17124 Background: The immunotherapy drug, nivolumab, is now approved for several metastatic cancers, and has resulted in responses previously not seen with these cancers. Molecular targeting agents, such as mammalian target of rapamycin (mTOR) inhibitor,… read more here.
Keywords: histology; targeting agents; molecular targeting; alone combination ... See more keywords
Computational Approaches to the Rational Design of Tubulin-Targeting Agents
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DOI: 10.3390/biom13020285
Abstract: Microtubules are highly dynamic polymers of α,β-tubulin dimers which play an essential role in numerous cellular processes such as cell proliferation and intracellular transport, making them an attractive target for cancer and neurodegeneration research. To… read more here.
Keywords: computational approaches; approaches rational; tubulin targeting; design ... See more keywords
Everything Comes with a Price: The Toxicity Profile of DNA-Damage Response Targeting Agents
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14040953
Abstract: Simple Summary DNA damage induces genome instability, which may elicit cancer development. Defects in the DNA repair machinery further enhance cancer predisposition, but can also be exploited as a therapeutic target. Indeed, targeted agents against… read more here.
Keywords: dna damage; cancer; ddr targeting; targeting agents ... See more keywords