Pre-targeting amyloid-β with antibodies for potential molecular imaging of Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d2cc06850h
Abstract: With the aim of developing the concept of pretargeted click chemistry for the diagnosis of Alzheimer's disease two antibodies specific for amyloid-β were modified to incorporate trans-cyclooctene functional groups. Two bis(thiosemicarbazone) compounds with pendant 1,2,4,5-tetrazine… read more here.
Keywords: disease; alzheimer disease; antibodies potential; amyloid antibodies ... See more keywords
Targeting amyloid clearance in Alzheimer's disease as a therapeutic strategy
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14593
Abstract: Targeting the amyloid‐β (Aβ) peptide cascade has been at the heart of therapeutic developments in Alzheimer's disease (AD) research for more than 25 years, yet no successful drugs have reached the marketplace based on this… read more here.
Keywords: clearance alzheimer; alzheimer disease; disease; clearance ... See more keywords
Nanoparticles targeting amyloid deposits: a potential contrast agent for diagnosis and treatment
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Nanophotonics"
DOI: 10.1117/1.jnp.15.026010
Abstract: Abstract. Amyloid-based diseases, such as amyloid light-chain amyloidosis, are characterized by misfolding of proteins and their deposition as amyloids in tissues. As prognosis is usually poor, patients suffering from these illnesses can benefit from improved… read more here.
Keywords: targeting amyloid; nanoparticles targeting; treatment; amyloid ... See more keywords