Therapeutic targeting of the angiopoietin–TIE pathway
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DOI: 10.1038/nrd.2016.278
Abstract: The endothelial angiopoietin (ANG)–TIE growth factor receptor pathway regulates vascular permeability and pathological vascular remodelling during inflammation, tumour angiogenesis and metastasis. Drugs that target the ANG–TIE pathway are in clinical development for oncological and ophthalmological… read more here.
Keywords: tie pathway; targeting angiopoietin; therapeutic targeting; ang tie ... See more keywords
Targeting angiopoietin‐like 3 in atherosclerosis: From bench to bedside
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DOI: 10.1111/dom.14450
Abstract: Atherosclerotic cardiovascular disease (ASCVD) is the largest cause of morbidity and mortality worldwide. Lipid‐lowering therapies are the current major cornerstone of ASCVD management. Statins, ezetimibe, fibrates and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors effectively… read more here.
Keywords: atherosclerosis bench; like atherosclerosis; targeting angiopoietin; bench bedside ... See more keywords