Impact of Mitochondrial Targeting Antibiotics on Mitochondrial Function and Proliferation of Cancer Cells.
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DOI: 10.1021/acsmedchemlett.0c00632
Abstract: Some marketed antibiotics can cause mitochondria dysfunction via inhibition of the mitochondrial translation process. There is great interest in exploiting such effects within a cancer setting. To enhance accumulation of antibiotics within the mitochondria of… read more here.
Keywords: antibiotics mitochondrial; targeting antibiotics; mitochondrial targeting; cancer cells ... See more keywords
Mutational Evolution of Pseudomonas aeruginosa Resistance to Ribosome-Targeting Antibiotics
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DOI: 10.3389/fgene.2018.00451
Abstract: The present work examines the evolutionary trajectories of replicate Pseudomonas aeruginosa cultures in presence of the ribosome-targeting antibiotics tobramycin and tigecycline. It is known that large number of mutations across different genes – and therefore… read more here.
Keywords: pseudomonas aeruginosa; ribosome targeting; evolution; targeting antibiotics ... See more keywords