Targeting autophagy using metallic nanoparticles: a promising strategy for cancer treatment
Sign Up to like & getrecommendations! Published in 2018 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-018-2973-y
Abstract: Despite the extensive genetic and phenotypic variations present in the different tumors, they frequently share common metabolic alterations, such as autophagy. Autophagy is a self-degradative process in response to stresses by which damaged macromolecules and… read more here.
Keywords: targeting autophagy; metallic nanoparticles; treatment; using metallic ... See more keywords
Glioblastoma: Targeting the autophagy in tumorigenesis
Sign Up to like & getrecommendations! Published in 2019 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2019.09.012
Abstract: Glioblastoma (GBM) is one of the most malignant and aggressive primary brain tumor, with a mean life expectancy of less than 15 months. The malignant nature of GBM prompts the need for further research on… read more here.
Keywords: targeting autophagy; research; tumorigenesis; glioblastoma ... See more keywords
Targeting autophagy with natural products to prevent SARS-CoV-2 infection
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Traditional and Complementary Medicine"
DOI: 10.1016/j.jtcme.2021.10.003
Abstract: Autophagy is a catabolic process that maintains internal homeostasis and energy balance through the lysosomal degradation of redundant or damaged cellular components. During virus infection, autophagy is triggered both in parenchymal and in immune cells… read more here.
Keywords: targeting autophagy; natural products; autophagy natural; infection ... See more keywords
Targeting autophagy in multiple myeloma.
Sign Up to like & getrecommendations! Published in 2017 at "Leukemia research"
DOI: 10.1016/j.leukres.2017.06.002
Abstract: Autophagy plays an important role in plasma cell ontogeny and in the pathophysiology of multiple myeloma. Autophagy is usually considered a pro-survival mechanism, and cooperates with the ubiquitin proteasome system in maintaining the homeostasis of… read more here.
Keywords: targeting autophagy; autophagy multiple; myeloma; multiple myeloma ... See more keywords
Targeting Autophagy-Related Epigenetic Regulators for Cancer Drug Discovery.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c00579
Abstract: Existing evidence has demonstrated that epigenetic modifications (including DNA methylation, histone modifications, and microRNAs), which are associated with the occurrence and development of tumors, can directly or indirectly regulate autophagy. In particular, nuclear events induced… read more here.
Keywords: epigenetic regulators; targeting autophagy; epigenetic drugs; autophagic process ... See more keywords
PD-L1-Targeting Autophagy Modulator to Upregulate MHC-I and Activate Photo-Immunotherapy for Metastatic Tumor Eradication.
Sign Up to like & getrecommendations! Published in 2025 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.5c00029
Abstract: Breast cancer cells are characterized by heightened autophagy, which impairs tumor-associated antigen presentation and represents a significant barrier to the antitumor immunity. In this study, a PD-L1-targeting autophagy modulator (PFC@CQ) is fabricated to activate the… read more here.
Keywords: autophagy modulator; targeting autophagy; tumor; cell ... See more keywords
Approaches for discovering novel bioactive small molecules targeting autophagy
Sign Up to like & getrecommendations! Published in 2017 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2017.1349751
Abstract: ABSTRACT Introduction: In recent years, development of novel bioactive small molecules targeting autophagy has been implicated for autophagy-related disease treatment. Screening new small molecules regulating autophagy allows for the discovery of novel autophagy machinery and… read more here.
Keywords: targeting autophagy; small molecules; bioactive small; novel bioactive ... See more keywords
Preclinical findings: The pharmacological targets and molecular mechanisms of ferulic acid treatment for COVID-19 and osteosarcoma via targeting autophagy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.971687
Abstract: The variant virus-based 2019 coronavirus disease (COVID-19) pandemic has reportedly impacted almost all populations globally, characterized by a huge number of infected individuals. Clinical evidence proves that patients with cancer are more easily infected with… read more here.
Keywords: pharmacology; targeting autophagy; covid; pharmacological targets ... See more keywords
Fountain of youth—Targeting autophagy in aging
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2023.1125739
Abstract: As our society ages inexorably, geroscience and research focusing on healthy aging is becoming increasingly urgent. Macroautophagy (referred to as autophagy), a highly conserved process of cellular clearance and rejuvenation has attracted much attention due… read more here.
Keywords: autophagy aging; fountain youth; targeting autophagy; pathology ... See more keywords
Targeting autophagy process in center nervous trauma
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2023.1128087
Abstract: The central nervous system (CNS) is the primary regulator of physiological activity, and when CNS is compromised, its physical functions are affected. Spinal cord injury (SCI) and traumatic brain injury (TBI) are common trauma in… read more here.
Keywords: trauma; targeting autophagy; center nervous; process center ... See more keywords
Targeting Autophagy for the Treatment of Alzheimer’s Disease: Challenges and Opportunities
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2019.00203
Abstract: Alzheimer’s disease (AD) is the most common type of dementia which characterized by a progressive loss of memory and cognitive function due to degeneration of synapses and axons. Currently, there is no cure for AD.… read more here.
Keywords: targeting autophagy; alzheimer disease; autophagy treatment; disease ... See more keywords