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Targeting BAX ubiquitin‐binding sites reveals that BAX activation is essential for its ubiquitin‐dependent degradation

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0 Published in 2019 at "Journal of Cellular Biochemistry"

DOI: 10.1002/jcb.29505

Abstract: BAX is an important proapoptotic protein of the BCL‐2 family, and its stability is essential for the regulation of the mitochondrial apoptotic pathway. A previous study revealed that BAX could undergo degradation through the ubiquitin‐proteasome… read more here.

Keywords: bax; degradation; ubiquitin binding; binding sites ... See more keywords