DPA-Zinc around Polyplexes Acts Like PEG to Reduce Protein Binding while Targeting Cancer Cells.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202203252
Abstract: Gene therapy holds great promise as an effective treatment for many diseases of genetic origin. Gene therapy works by employing cationic polymers, liposomes, and nanoparticles to condense DNA into polyplexes via electronic interactions.Then, a therapeutic… read more here.
Keywords: binding targeting; protein binding; targeting cancer; gene ... See more keywords
Targeting cancer energy metabolism: a potential systemic cure for cancer
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Pharmacal Research"
DOI: 10.1007/s12272-019-01115-2
Abstract: Long-term investigation and extensive efforts using sequencing and -omics analysis identified thousands of mutations in a single tumor. However, we cannot succeed at curing cancer by targeting mutations as the cause of cancer. Therefore, as… read more here.
Keywords: targeting cancer; cancer energy; metabolism; cancer ... See more keywords
Targeting PD-1 in cancer: Biological insights with a focus on breast cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Critical reviews in oncology/hematology"
DOI: 10.1016/j.critrevonc.2019.07.011
Abstract: Programmed cell death-1 (PD-1) receptor and its ligands physiologically regulate the activity of the adaptive immune system to limit excessive inflammatory processes, thus preventing normal tissue damage. Tumor cells escape from the host immune surveillance… read more here.
Keywords: targeting cancer; cancer biological; biological insights; breast cancer ... See more keywords
Combinatorial targeting of cancer bone metastasis using mRNA engineered stem cells
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.06.047
Abstract: Background Bone metastases are common and devastating to cancer patients. Existing treatments do not specifically target the disease sites and are therefore ineffective and systemically toxic. Here we present a new strategy to treat bone… read more here.
Keywords: targeting cancer; bone; bone metastasis; cancer ... See more keywords
Targeting cancer stem cells by nutraceuticals for cancer therapy.
Sign Up to like & getrecommendations! Published in 2021 at "Seminars in cancer biology"
DOI: 10.1016/j.semcancer.2021.07.008
Abstract: Accumulating evidence has demonstrated that cancer stem cells (CSCs) play an essential role in tumor progression and reoccurrence and drug resistance. Multiple signaling pathways have been revealed to be critically participated in CSC development and… read more here.
Keywords: cancer stem; targeting cancer; cells nutraceuticals; cancer ... See more keywords
Targeting Cancer Stemness in the Clinic: From Hype to Hope.
Sign Up to like & getrecommendations! Published in 2019 at "Cell stem cell"
DOI: 10.1016/j.stem.2018.11.017
Abstract: Tumors are composed of non-homogeneous cell populations exhibiting varying degrees of genetic and functional heterogeneity. Cancer stem cells (CSCs) are capable of sustaining tumors by manipulating genetic and non-genetic factors to metastasize, resist treatment, and… read more here.
Keywords: targeting cancer; cancer stemness; clinic hype; stemness clinic ... See more keywords
Targeting the cancer mutanome of breast cancer
Sign Up to like & getrecommendations! Published in 2018 at "Nature Medicine"
DOI: 10.1038/s41591-018-0065-z
Abstract: A metastatic hormone receptor–positive breast cancer, usually resistant to immunotherapy, is successfully treated with tumor-infiltrating lymphocytes enriched for neoantigen reactivity, underscoring the broad potential of this immunotherapeutic approach. read more here.
Keywords: targeting cancer; breast cancer; cancer; mutanome breast ... See more keywords
Advanced Boron Neutron Capture Therapy Targeting Cancer Stem Cells by Selective Induction of LAT1 Overexpression.
Sign Up to like & getrecommendations! Published in 2023 at "Radiation research"
DOI: 10.1667/rade-22-00195.1
Abstract: This study conducted fundamental research to develop a more effective BNCT targeting cancer stem cells. We constructed plasmids that induced the overexpression of L-type amino acid transporter 1 (LAT1) tagged with tdTomato on the cytoplasmic… read more here.
Keywords: cancer stem; lat1; targeting cancer; stem cells ... See more keywords
Selective Targeting of Cancer Cells by Copper Ionophores: An Overview
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.841814
Abstract: Conventional cancer therapies suffer from severe off-target effects because most of them target critical facets of cells that are generally shared by all rapidly proliferating cells. The development of new therapeutic agents should aim to… read more here.
Keywords: cancer; cells copper; targeting cancer; cancer cells ... See more keywords
Molecular Docking as a Therapeutic Approach for Targeting Cancer Stem Cell Metabolic Processes
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.768556
Abstract: Cancer stem cells (CSCs) are subpopulation of cells which have been demonstrated in a variety of cancer models and involved in cancer initiation, progression, and development. Indeed, CSCs which seem to form a small percentage… read more here.
Keywords: molecular docking; stem cell; cancer stem; targeting cancer ... See more keywords
Dynamic Targeting in Cancer Treatment
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2019.00096
Abstract: With the advent of personalized medicine, design and development of anti-cancer drugs that are specifically targeted to individual or sets of genes or proteins has been an active research area in both academia and industry.… read more here.
Keywords: network; targeting cancer; cancer treatment; cancer ... See more keywords