Targeting CAR T cells to glioblastoma
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Drug Discovery"
DOI: 10.1038/d41573-020-00034-y
Abstract: Discovering new antibiotics capable of tackling resistant bacteria is increasingly difficult. Stokes et al. train a deep neural network model to predict molecules with antibacterial activity. Applying the model to the Drug Repurposing Hub identified… read more here.
Keywords: cells glioblastoma; targeting car; car cells;
IMMU-72. Locoregionally delivered PD-1 blockade augments B7-H3 targeting CAR T cell efficacy in models of glioblastoma
Sign Up to like & getrecommendations! Published in 2025 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaf201.0870
Abstract: Glioblastoma (GBM) is the most lethal primary brain tumor in adults presenting with a 95% five-year mortality rate. Due to high relapse rates, GBM remains a major unmet clinical need for new treatment approaches. An… read more here.
Keywords: blockade; car cell; car; car cells ... See more keywords
CD19-targeting CAR T cells protect from ANCA-induced acute kidney injury
Sign Up to like & getrecommendations! Published in 2024 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/ard-2023-224875
Abstract: Objectives Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides (AAV) are life-threatening systemic autoimmune diseases manifesting in the kidneys as necrotizing crescentic glomerulonephritis (NCGN). ANCA antigens are myeloperoxidase (MPO) or proteinase 3. Current treatments include steroids, cytotoxic drugs… read more here.
Keywords: cd19 targeting; car; car cells; anca induced ... See more keywords
Abstract 3199: Development of a flow cytometry-based assay for measuring specific CAR expression on LGR5-targeting CAR-T cells
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3199
Abstract: The measurement of chimeric antigen receptor (CAR) expression is critical for the development, qualification and quantitation of CAR-T cells for clinical applications. There is a comprehensive range of tools commercially available for specifically measuring expression… read more here.
Keywords: car expression; targeting car; development; expression ... See more keywords
Abstract 4085: Development and in vitro validation of an LGR-5 targeting CAR-T against colorectal cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4085
Abstract: Chimeric antigen receptor (CAR) T cells have demonstrated robust clinical efficacy against B-cell malignancies, and rapid translation to approval for use in man has inspired the search for CAR-T cells against solid tumours. Cancer stem… read more here.
Keywords: lgr5; cell; targeting car; car ... See more keywords
Abstract 5228: Engineering CD123-targeting vδ1-enriched γδT cells with enhanced preclinical efficacy and safety profile
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-5228
Abstract: Acute myeloid leukemia (AML) is an aggressive hematological malignancy that, despite advances in treatment, has an overall 5-year survival rate of less than 30%. There is an urgent unmet need for new and effective therapies… read more here.
Keywords: cd123 targeting; targeting car; enriched cells; cell ... See more keywords
A novel loop-structured CD19/CD22 dual-targeting CAR-T therapy for patients with refractory/relapsed B-cell non-Hodgkin lymphoma
Sign Up to like & getrecommendations! Published in 2025 at "Blood"
DOI: 10.1182/blood-2025-4152
Abstract: BackgroundCAR-T cell therapy has demonstrated significant efficacy in B-cell malignancies, but relapse due to target antigen loss remains a challenge. To address antigen escape and expression heterogeneity, we developed four CD19/CD22 CAR constructs with different… read more here.
Keywords: car therapy; dual targeting; car; cell ... See more keywords
Influence of HIV on outcomes in patients with diffuse large B cell lymphoma treated with CD19 targeting CAR-T cell therapy.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2025.43.16_suppl.7076
Abstract: 7076 Background: HIV+ patients have an 18-fold increased risk of developing diffuse large B Cell Lymphoma (DLBCL). There is uncertainty in the literature regarding the safety and efficacy of chimeric antigen receptor T-cell (CAR-T) therapy… read more here.
Keywords: hiv; therapy; car; cell ... See more keywords
Current Status and Perspectives of Dual-Targeting Chimeric Antigen Receptor T-Cell Therapy for the Treatment of Hematological Malignancies
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14133230
Abstract: Simple Summary Approved chimeric antigen receptor (CAR) T cells recognize and bind to only one tumor target (single-targeted CAR T cells, Si-CART) on cancer cells by the special receptor and followed with activation, thus removing… read more here.
Keywords: cell; dual targeting; targeting car; cell therapy ... See more keywords