Targeting CAR T cells to glioblastoma
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Drug Discovery"
DOI: 10.1038/d41573-020-00034-y
Abstract: Discovering new antibiotics capable of tackling resistant bacteria is increasingly difficult. Stokes et al. train a deep neural network model to predict molecules with antibacterial activity. Applying the model to the Drug Repurposing Hub identified… read more here.
Keywords: cells glioblastoma; targeting car; car cells;
Abstract 3199: Development of a flow cytometry-based assay for measuring specific CAR expression on LGR5-targeting CAR-T cells
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3199
Abstract: The measurement of chimeric antigen receptor (CAR) expression is critical for the development, qualification and quantitation of CAR-T cells for clinical applications. There is a comprehensive range of tools commercially available for specifically measuring expression… read more here.
Keywords: car expression; targeting car; development; expression ... See more keywords
Abstract 4085: Development and in vitro validation of an LGR-5 targeting CAR-T against colorectal cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4085
Abstract: Chimeric antigen receptor (CAR) T cells have demonstrated robust clinical efficacy against B-cell malignancies, and rapid translation to approval for use in man has inspired the search for CAR-T cells against solid tumours. Cancer stem… read more here.
Keywords: lgr5; cell; targeting car; car ... See more keywords
Current Status and Perspectives of Dual-Targeting Chimeric Antigen Receptor T-Cell Therapy for the Treatment of Hematological Malignancies
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DOI: 10.3390/cancers14133230
Abstract: Simple Summary Approved chimeric antigen receptor (CAR) T cells recognize and bind to only one tumor target (single-targeted CAR T cells, Si-CART) on cancer cells by the special receptor and followed with activation, thus removing… read more here.
Keywords: cell; dual targeting; targeting car; cell therapy ... See more keywords