Targeting β‐catenin in hepatocellular cancers induced by coexpression of mutant β‐catenin and K‐Ras in mice
Sign Up to like & getrecommendations! Published in 2017 at "Hepatology"
DOI: 10.1002/hep.28975
Abstract: Recently, we have shown that coexpression of hMet and mutant‐β‐catenin using sleeping beauty transposon/transposase leads to hepatocellular carcinoma (HCC) in mice that corresponds to around 10% of human HCC. In the current study, we investigate… read more here.
Keywords: targeting catenin; hcc; catenin; mutant catenin ... See more keywords
MicroRNA-939 governs vascular integrity and angiogenesis through targeting γ-catenin in endothelial cells.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.01.085
Abstract: Coronary collateral circulation (CCC) functions as a natural bypass in the event of coronary obstruction, which markedly improves prognosis in patients with coronary artery disease (CAD). MicroRNAs (miRNAs) have been implicated in multiple physiological and… read more here.
Keywords: targeting catenin; angiogenesis; mir 939; vascular integrity ... See more keywords
Targeting β-catenin in acute myeloid leukaemia: past, present, and future perspectives
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DOI: 10.1042/bsr20211841
Abstract: Abstract Acute myeloid leukaemia (AML) is an aggressive disease of the bone marrow with a poor prognosis. Evidence suggests long established chemotherapeutic regimens used to treat AML are reaching the limits of their efficacy, necessitating… read more here.
Keywords: catenin acute; leukaemia; targeting catenin; acute myeloid ... See more keywords
Abstract 803: Targeting β-catenin/CBP signaling in OSCC
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-803
Abstract: Objectives: Oral squamous cell carcinoma (OSCC) is an aggressive malignancy characterized by molecular heterogeneity and locoregional spread associated with high morbidity. Aggressive cancers are thought to arise from populations of cancer initiating cells (CICs) that… read more here.
Keywords: targeting catenin; catenin cbp; catenin; cd44 cd24 ... See more keywords