Macrophage Associated Immune Checkpoint CD47 Blocking Ameliorates Endometriosis.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular human reproduction"
DOI: 10.1093/molehr/gaac010
Abstract: Peritoneal macrophages play a significant role in the progression of endometriosis (EM), but their functional differentiation is still unclear, and their phagocytic ability is weak. CD47-SIRPα and PD-L1-PD-1 are considered immune checkpoints associated with macrophage… read more here.
Keywords: macrophage; phagocytosis; targeting cd47; cd47 ... See more keywords
Targeting the CD47/thrombospondin-1 signaling axis regulates immune cell bioenergetics in the tumor microenvironment to potentiate antitumor immune response
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-004712
Abstract: Background CD47 is an integral membrane protein that alters adaptive immunosurveillance when bound to the matricellular glycoprotein thrombospondin-1 (TSP1). We examined the impact of the CD47/TSP1 signaling axis on melanoma patient response to anti-PD-1 therapy… read more here.
Keywords: targeting cd47; melanoma; cd47 tsp1; cd47 ... See more keywords
Targeting CD47 and Autophagy Elicited Enhanced Antitumor Effects in Non–Small Cell Lung Cancer
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-16-0398
Abstract: Blocking CD47 interactions was a potent antitumor therapy for NSCLC. Cells resist death by increasing autophagy; simultaneously inhibiting autophagy provided a synergistic antitumor effect, providing a scientific basis for enhancing the efficacy of immune checkpoint… read more here.
Keywords: cd47 autophagy; targeting cd47; autophagy; cancer ... See more keywords
Targeting CD47: the achievements and concerns of current studies on cancer immunotherapy.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of thoracic disease"
DOI: 10.21037/jtd.2017.02.30
Abstract: Targeting CD47 is in the spotlight of cancer immunotherapy. Blocking CD47 triggers the recognition and elimination of cancer cells by the innate immunity. There are three CD47 antagonists in phase I clinical trials, but their… read more here.
Keywords: cd47; targeting cd47; cd47 achievements; cancer immunotherapy ... See more keywords
Advances in Anti-Metabolic Disease Treatments Targeting CD47.
Sign Up to like & getrecommendations! Published in 2022 at "Current pharmaceutical design"
DOI: 10.2174/1381612828666221006123144
Abstract: Metabolic disorders include a cluster of conditions that result from hyperglycemia, hyperlipidemia, insulin resistance, obesity, and hepatic steatosis, which cause the dysfunction of immune cells and innate cells such as macrophages, natural killer cells, vascular… read more here.
Keywords: targeting cd47; metabolic disease; metabolic diseases; cd47 ... See more keywords
Targeting CD47 as a Novel Immunotherapy for Breast Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.924740
Abstract: Nowadays, breast cancer has become the most common cancer worldwide with a high mortality rate. Immune checkpoint blockade holds great promise in tumor‐targeted therapy, and CD47 blockade as one immune therapy is undergoing various preclinical… read more here.
Keywords: cd47 novel; targeting cd47; breast cancer; novel immunotherapy ... See more keywords