MDB-18. SYNERGISTIC TARGETING OF CDK8 AND MTOR FOR MYC-DRIVEN MEDULLOBLASTOMA
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DOI: 10.1093/neuonc/noae064.467
Abstract: Abstract MYC-driven medulloblastoma represents a highly aggressive subgroup with poor prognosis and limited treatment options. CRISPR-Cas9 screening across MB cell lines revealed cyclin-dependent kinase 8 (CDK8) as a top dependency for MB growth. Loss of… read more here.
Keywords: targeting cdk8; cdk8; myc driven; driven medulloblastoma ... See more keywords