Promiscuous Targeting of Cellular Proteins by Vpr Drives Systems-Level Proteomic Remodeling in HIV-1 Infection
Sign Up to like & getrecommendations! Published in 2019 at "Cell Reports"
DOI: 10.1016/j.celrep.2019.04.025
Abstract: Summary HIV-1 encodes four “accessory proteins” (Vif, Vpr, Vpu, and Nef), dispensable for viral replication in vitro but essential for viral pathogenesis in vivo. Well characterized cellular targets have been associated with Vif, Vpu, and… read more here.
Keywords: promiscuous targeting; proteins vpr; targeting cellular; cellular proteins ... See more keywords
Corrigendum: Targeting cellular senescence prevents age-related bone loss in mice
Sign Up to like & getrecommendations! Published in 2017 at "Nature Medicine"
DOI: 10.1038/nm1117-1384c
Abstract: This corrects the article DOI: 10.1038/nm.4385 read more here.
Keywords: age related; senescence prevents; targeting cellular; corrigendum targeting ... See more keywords
Targeting cellular metabolism to reduce head and neck cancer growth
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-41523-4
Abstract: Head and neck squamous cell carcinoma (HNSCC) presents a major public health concern because of delayed diagnosis and poor prognosis. Malignant cells often reprogram their metabolism in order to promote their survival and proliferation. Aberrant… read more here.
Keywords: metabolism; cellular metabolism; targeting cellular; cancer ... See more keywords
Targeting Cellular Senescence in Cancer and Aging: Roles of p53 and its Isoforms.
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DOI: 10.1093/carcin/bgaa071
Abstract: Cellular senescence and the associated secretory phenotype (SASP) promote disease in the aged population. Targeting senescent cells by means of removal, modulation of SASP, or through cellular reprogramming, represents a novel therapeutic avenue for treating… read more here.
Keywords: senescence; p53 isoforms; targeting cellular; cellular senescence ... See more keywords
Therapeutic targeting of cellular stress responses in cancer
Sign Up to like & getrecommendations! Published in 2018 at "Thoracic Cancer"
DOI: 10.1111/1759-7714.12890
Abstract: Similar to bacteria, yeast, and other organisms that have evolved pathways to respond to environmental stresses, cancer cells develop mechanisms that increase genetic diversity to facilitate adaptation to a variety of stressful conditions, including hypoxia,… read more here.
Keywords: cancer therapeutic; therapeutic targeting; targeting cellular; cellular stress ... See more keywords
Targeting Cellular Iron Homeostasis with Ironomycin in Diffuse Large B-cell Lymphoma
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Research"
DOI: 10.1158/0008-5472.can-21-0218
Abstract: Iron homeostasis represents a potential therapeutic target for high-risk patients with DLBCL that can be targeted with ironomycin to induce cell death and to sensitize tumor cells to conventional treatments. read more here.
Keywords: cell; targeting cellular; iron; iron homeostasis ... See more keywords
Targeting cellular gaps using Janus nanoparticles containing cationic polymers and surfactant lipids.
Sign Up to like & getrecommendations! Published in 2023 at "Drug discoveries & therapeutics"
DOI: 10.5582/ddt.2022.01118
Abstract: Since nanoparticles are taken up into cells by endocytosis, phagocytosis, or pinocytosis, they have been studied as intracellular drug carriers. Janus particles have an anisotropic structure composed of two or more distinct domains and have… read more here.
Keywords: targeting cellular; cellular gaps; gaps using; surfactant lipids ... See more keywords