Optimization of Benzamide Derivatives as Potent and Orally Active Tubulin Inhibitors Targeting the Colchicine Binding Site.
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DOI: 10.1021/acs.jmedchem.2c01208
Abstract: Targeting the colchicine binding site on tubulin is a promising strategy to develop cancer therapeutics. Herein, we describe our systematic structure-activity relationship studies of benzamide derivatives that lead to an identification of a potent and… read more here.
Keywords: tubulin; benzamide derivatives; colchicine binding; targeting colchicine ... See more keywords