Selective targeting of collagen IV in the cancer cell microenvironment reduces tumor burden
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DOI: 10.18632/oncotarget.24280
Abstract: Goodpasture antigen-binding protein (GPBP) is an exportable1 Ser/Thr kinase that induces collagen IV expansion and has been associated with chemoresistance following epithelial-to-mesenchymal transition (EMT). Here we demonstrate that cancer EMT phenotypes secrete GPBP (mesenchymal GPBP)… read more here.
Keywords: targeting collagen; cancer; gpbp; cell microenvironment ... See more keywords