Therapeutic targeting of differentiation-state dependent metabolic vulnerabilities in diffuse midline glioma
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-52973-4
Abstract: H3K27M diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPG), exhibit cellular heterogeneity comprising less-differentiated oligodendrocyte precursors (OPC)-like stem cells and more differentiated astrocyte (AC)-like cells. Here, we establish in vitro models that recapitulate… read more here.
Keywords: like cells; therapeutic targeting; targeting differentiation; opc like ... See more keywords