Targeting the α4-α5 dimerization interface of K-RAS inhibits tumor formation in vivo
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DOI: 10.1038/s41388-018-0636-y
Abstract: RAS genes are the most commonly mutated oncogenes in human cancers. Despite tremendous efforts over the past several decades, however, RAS-specific inhibitors remain elusive. Thus, targeting RAS remains a highly sought-after goal of cancer research.… read more here.
Keywords: dimerization; targeting dimerization; dimerization interface; tumor formation ... See more keywords