Recent advances in targeting DNA repair pathways for the treatment of ovarian cancer and their clinical relevance
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Clinical Oncology"
DOI: 10.1007/s10147-017-1137-7
Abstract: Poly (ADP-ribose) polymerase (PARP) inhibitors have attracted much attention as one of the major molecular-targeted therapeutics for inhibiting DNA damage response. The PARP inhibitor, olaparib, has been clinically applied for treating certain recurrent ovarian cancer… read more here.
Keywords: targeting dna; cancer clinical; advances targeting; ovarian cancer ... See more keywords
Targeting DNA repair for precision radiotherapy: Balancing the therapeutic ratio.
Sign Up to like & getrecommendations! Published in 2017 at "Current problems in cancer"
DOI: 10.1016/j.currproblcancer.2017.04.002
Abstract: Genomic instability is underpinned by defects in the DNA damage response and DNA repair pathways. Subsequent clonal selection and adaption can lead to a mutator phenotype and tumor aggression. Importantly, tumor cell sensitivity to chemotherapy… read more here.
Keywords: targeting dna; precision radiotherapy; dna repair; repair ... See more keywords
Development of Novel 191Pt-Labeled Hoechst33258: 191Pt Is More Suitable than 111In for Targeting DNA.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c02209
Abstract: This study aims to establish new labeling methods for no-carrier-added radio-Pt (191Pt) and to evaluate the in vitro properties of 191Pt-labeled agents compared with those of agents labeled with the common emitter 111In. 191Pt was… read more here.
Keywords: dna; labeled hoechst33258; 191pt labeled; dtpa ... See more keywords
A Nucleus-Targeting DNA Aptamer for Dead Cell Indication.
Sign Up to like & getrecommendations! Published in 2019 at "ACS sensors"
DOI: 10.1021/acssensors.9b00342
Abstract: Dead cells always accompany with live cells in vivo and in cell culture. It is important to distinguish dead cells from live cells in various biological studies. Currently, the probes for dead cells are mainly… read more here.
Keywords: nucleus targeting; targeting dna; live cells; dead cells ... See more keywords
Targeting DNA repair in gliomas.
Sign Up to like & getrecommendations! Published in 2019 at "Current Opinion in Neurology"
DOI: 10.1097/wco.0000000000000760
Abstract: PURPOSE OF REVIEW Gliomas represent a disparate group of malignancies with varying clinical outcomes despite a tremendous amount of time, effort, and resources dedicated to their management and understanding. The most aggressive entity, glioblastoma, has… read more here.
Keywords: dna repair; repair gliomas; targeting dna; neurology ... See more keywords
Pleiotropic Impact of DNA-PK in Cancer and Implications for Therapeutic Strategies
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-18-2207
Abstract: Purpose: DNA-dependent protein kinase catalytic subunit (DNA-PK) is a pleiotropic kinase involved in DNA repair and transcriptional regulation. DNA-PK is deregulated in selected cancer types and is strongly associated with poor outcome. The underlying mechanisms… read more here.
Keywords: dna; targeting dna; cancer; pleiotropic impact ... See more keywords
Abstract LB-119: Targeting DNA-PK via small molecule inhibitors of the Ku-DNA interaction
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-lb-119
Abstract: DNA-PK, the DNA-dependent protein kinase, is a validated target for cancer therapeutics that drives the DNA damage response and plays a critical role in the nonhomologous end joining (NHEJ) DNA repair pathway. Inhibition of DNA-PK… read more here.
Keywords: targeting dna; dna; dna interaction; cancer ... See more keywords
Abstract 4572: 3D-EXpress ex vivo platform using a biorepository of characterized fresh patient tumoroids allows development of rational combinations with drugs targeting DNA damage response and immune checkpoint blockade
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4572
Abstract: Introduction: Nilogen Oncosystems’ 3D-EXpress platform allows for the detailed characterization offreshly resected patient tumor tissue for inclusion in studies investigating rational combinations of IOtherapeutics. Incorporating data on immune cell composition, tumor cell target expression, mutationalstatus,… read more here.
Keywords: targeting dna; platform; dna damage; tumor ... See more keywords
Targeting DNA damage repair in small cell lung cancer and the biomarker landscape.
Sign Up to like & getrecommendations! Published in 2018 at "Translational lung cancer research"
DOI: 10.21037/tlcr.2018.02.03
Abstract: Small cell lung cancer (SCLC) is an aggressive malignancy that accounts for 14% of all lung cancer diagnoses. Despite decades of active research, treatment options for SCLC are limited and resistance to the few Food… read more here.
Keywords: targeting dna; cell lung; lung cancer; small cell ... See more keywords
Targeting DNA Methyltranferases in Urological Tumors
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2018.00366
Abstract: Urological cancers are a heterogeneous group of malignancies accounting for a considerable proportion of cancer-related morbidity and mortality worldwide. Aberrant epigenetic traits, especially altered DNA methylation patterns constitute a hallmark of these tumors. Nonetheless, these… read more here.
Keywords: methyltranferases urological; targeting dna; dna methyltranferases; urological tumors ... See more keywords
Targeting the DNA Damage Response to Overcome Cancer Drug Resistance in Glioblastoma
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21144910
Abstract: Glioblastoma multiforme (GBM) is a severe brain tumor whose ability to mutate and adapt to therapies is at the base for the extremely poor survival rate of patients. Despite multiple efforts to develop alternative forms… read more here.
Keywords: dna damage; damage response; glioblastoma; targeting dna ... See more keywords