A Scoping Review Protocol to Explore the Use of Interleukin-1-Targeting Drugs for the Treatment of Dermatological Diseases: Indications, Mechanism of Action, Efficacy, and Safety
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DOI: 10.1007/s13555-018-0235-4
Abstract: IntroductionThe interleukin (IL)-1 pathway has been identified as being involved in inflammatory and neoplastic skin diseases such as psoriasis, atopic dermatitis, neutrophilic dermatosis, melanoma, and squamous cell carcinoma. Drugs developed to target the IL-1 pathway… read more here.
Keywords: methodology; treatment dermatological; dermatology; evidence ... See more keywords
Inhibition of CDK8/19 Mediator kinase potentiates HER2-targeting drugs and bypasses resistance to these agents in vitro and in vivo
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DOI: 10.1073/pnas.2201073119
Abstract: Significance Breast cancers that overexpress oncogenic tyrosine kinase receptor HER2 are treated with HER2-targeting antibodies (such as trastuzumab) or small-molecule kinase inhibitors (such as lapatinib). However, most patients with metastatic HER2+ breast cancer have intrinsic… read more here.
Keywords: kinase; her2 targeting; cdk8; resistance ... See more keywords
Polymyxin and lipopeptide antibiotics: membrane-targeting drugs of last resort
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DOI: 10.1099/mic.0.001136
Abstract: The polymyxin and lipopeptide classes of antibiotics are membrane-targeting drugs of last resort used to treat infections caused by multi-drug-resistant pathogens. Despite similar structures, these two antibiotic classes have distinct modes of action and clinical… read more here.
Keywords: membrane targeting; targeting drugs; antibiotics membrane; last resort ... See more keywords