Exploring the relationship of hyaluronic acid molecular weight and active targeting efficiency for designing hyaluronic acid-modified nanoparticles
Sign Up to like & getrecommendations! Published in 2019 at "Asian Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ajps.2018.11.002
Abstract: Although it is reported that the targeting ability of hyaluronic acid (HA)-based nanoparticles (NPs) is molecular weight (MW) dependent, the influence of HA MW on targeting efficiency of HA-functionalized NPs and the underlying mechanism remain… read more here.
Keywords: targeting efficiency; molecular weight; dox; hyaluronic acid ... See more keywords
Brain targeting efficiency of antimigrain drug loaded mucoadhesive intranasal nanoemulsion.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.07.030
Abstract: Zolmitriptan (ZT) is a well-tolerated drug in migraine treatment suffering from low bioavailability due to low amount of the drug that reaches the brain after oral and nasal delivery. Development of new nasal mucoadhesive nanoemulsion… read more here.
Keywords: targeting efficiency; drug; mucoadhesive nanoemulsion; brain ... See more keywords
RNA-based CRISPR-Mediated Loss-of-Function Mutagenesis in Human Pluripotent Stem Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2020.04.017
Abstract: Current approaches for Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-Associated-9 (Cas9)-mediated genome editing in human pluripotent stem (PS) cells mainly employ plasmids or ribonucleoprotein complexes. Here, we devise an improved transfection protocol of in vitro… read more here.
Keywords: human pluripotent; targeting efficiency; rna based; pluripotent stem ... See more keywords
Evaluation of Targeting Efficiency of Joints with Anticollagen II Antibodies.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.9b00059
Abstract: Diseases of the joints affect over 10% of the world's population, resulting in significant morbidity. There is an unmet need in strategies for specific delivery of therapeutics to the joints. Collagen type II is synthesized… read more here.
Keywords: collagen; targeting efficiency; times higher; evaluation targeting ... See more keywords
Tandem Peptide Based on Structural Modification of Poly-Arginine for Enhancing Tumor Targeting Efficiency and Therapeutic Effect.
Sign Up to like & getrecommendations! Published in 2017 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.6b12611
Abstract: The nonselectivity of cell penetrating peptides had greatly limited the application in systemic administration. By conjugating a dGR motif to the C-terminal of octa-arginine, the formed tandem peptide R8-dGR had been proved to specifically recognize… read more here.
Keywords: poly arginine; tumor targeting; targeting efficiency; tumor ... See more keywords
A New EBS2b-IBS2b Base Paring (A−8/T−8) Improved the Gene-Targeting Efficiency of Thermotargetron in Escherichia coli
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.03159-22
Abstract: The randomized base pairing in the interval of IBS2 and IBS1 of Tel3c/4c intron (−8 and −7 sites) in Thermotargetron (TMT) results in a low success rate and gene-targeting efficiency in bacteria. In the present… read more here.
Keywords: intron; gene targeting; gene; base ... See more keywords
Patient-Friendly, Olfactory-Targeted, Stimuli-Responsive Hydrogels for Cerebral Degenerative Disorders Ensured > 400% Brain Targeting Efficiency in Rats.
Sign Up to like & getrecommendations! Published in 2020 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-020-01872-0
Abstract: Non-invasive brain therapy for chronic neurological disorders is in high demand. Vinpocetine (VIN) tablets for cerebrovascular degenerative disorders ensued 8 h, while CP-HPMC-SA hydrogels were mucoadhesive in simulated nasal fluid, owing to pH and ion-activated gelation.… read more here.
Keywords: hpmc; degenerative disorders; targeting efficiency; brain ... See more keywords
Recent advances in the development of biocompatible nanocarriers and their cancer cell targeting efficiency in photodynamic therapy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2022.969809
Abstract: In recent years, the role of biocompatible nanocarriers (BNs) and their cancer cell targeting efficiency in photodynamic therapy (PDT) holds potential benefits for cancer treatment. Biocompatible and biodegradable nanoparticles are successfully used as carrier molecules… read more here.
Keywords: chemistry; biocompatible nanocarriers; cell targeting; cancer cell ... See more keywords
The Impact of Nanobody Density on the Targeting Efficiency of PEGylated Liposomes
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232314974
Abstract: Nanoparticles (NPs) are commonly modified with tumor-targeting moieties that recognize proteins overexpressed on the extracellular membrane to increase their specific interaction with target cells. Nanobodies (Nbs), the variable domain of heavy chain-only antibodies, are a… read more here.
Keywords: density; nbs per; per liposome; pegylated liposomes ... See more keywords