Near‐infrared photoimmunotherapy targeting EGFR—Shedding new light on glioblastoma treatment
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Cancer"
DOI: 10.1002/ijc.31246
Abstract: Glioblastomas (GBMs) are high‐grade brain tumors, differentially driven by alterations (amplification, deletion or missense mutations) in the epidermal growth factor receptor (EGFR), that carry a poor prognosis of just 12–15 months following standard therapy. A… read more here.
Keywords: response; near infrared; treatment; photoimmunotherapy ... See more keywords
Discovery of Potent PROTACs Targeting EGFR Mutants through the Optimization of Covalent EGFR Ligands.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01827
Abstract: Drug resistance caused by epidermal growth factor receptor (EGFR) mutation has largely limited the clinical use of EGFR tyrosine kinase inhibitors (EGFR-TKIs) for the treatment of non-small-cell lung cancer (NSCLC). Herein, to overcome the intractable… read more here.
Keywords: protacs targeting; egfr mutants; targeting egfr; covalent ... See more keywords
Targeting the EGFR pathway shows promise for OA
Sign Up to like & getrecommendations! Published in 2021 at "Nature Reviews Rheumatology"
DOI: 10.1038/s41584-021-00583-5
Abstract: 0123456789();: while enabling prolonged retention and high cartilage penetration. Similar to EGFR overactivation, intra-articular delivery of these TGFα-conjugated nanoparticles in the knees of mice attenuated the development of surgery-induced OA. “We are currently collaborating with… read more here.
Keywords: egfr pathway; rheumatology; pathway shows; shows promise ... See more keywords
Allosterically targeting EGFR drug-resistance gatekeeper mutations.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of thoracic disease"
DOI: 10.21037/jtd.2017.06.43
Abstract: Lung cancer is by far the leading cause of cancer-related death with nearly 1.7 million deaths worldwide in 2016. The most common type of lung cancer is non-small cell lung cancer (NSCLC) accounting for 80%… read more here.
Keywords: lung cancer; allosterically targeting; targeting egfr; cancer ... See more keywords