Targeting Eph/ephrin system in cancer therapy.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.07.029
Abstract: It is well established that the Eph/ephrin system plays a central role in the embryonic development, with minor implications in the physiology of the adult. However, it is overexpressed and deregulated in a variety of… read more here.
Keywords: eph ephrin; system; ephrin system; targeting eph ... See more keywords
UniPR1331, a small molecule targeting Eph/ephrin interaction, prolongs survival in glioblastoma and potentiates the effect of antiangiogenic therapy in mice
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.25272
Abstract: Glioblastoma multiforme (GBM) is the most malignant brain tumor, showing high resistance to standard therapeutic approaches that combine surgery, radiotherapy, and chemotherapy. As opposed to healthy tissues, EphA2 has been found highly expressed in specimens… read more here.
Keywords: eph ephrin; glioblastoma; small molecule; molecule targeting ... See more keywords
Drug Conjugates for Targeting Eph Receptors in Glioblastoma
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceuticals"
DOI: 10.3390/ph13040077
Abstract: Glioblastoma (GBM) is a complex and heterogeneous tumor that warrants a comprehensive therapeutic approach for treatment. Tumor-associated antigens offer an opportunity to selectively target various components of the GBM microenvironment while sparing the normal cells… read more here.
Keywords: drug conjugates; eph receptors; targeting eph; conjugates targeting ... See more keywords
Antibody Targeting of Eph Receptors in Cancer
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceuticals"
DOI: 10.3390/ph13050088
Abstract: The Eph subfamily of receptor tyrosine kinases mediate cell-cell communication controlling cell and tissue patterning during development. While generally less active in adult tissues, they often re-emerge in cancers, particularly on undifferentiated or progenitor cells… read more here.
Keywords: eph receptors; antibody targeting; targeting eph; receptors cancer ... See more keywords