Epigenetic regulation of radioresistance: insights from preclinical and clinical studies
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2022.2158810
Abstract: ABSTRACT Introduction Oftentimes, radiation therapy (RT) is ineffective due to the development of radioresistance (RR). However, studies have shown that targeting epigenetic modifiers to enhance radiosensitivity represents a promising direction of clinical investigation. Areas covered… read more here.
Keywords: targeting epigenetic; preclinical clinical; clinical studies; epigenetic modifiers ... See more keywords
DIPG-12. TARGETING EPIGENETIC MODIFIERS TO INDUCE IMMUNE SIGNALING IN DIPG
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaa222.062
Abstract: Abstract DIPG is a universally fatal pediatric brainstem tumor with no effective therapy. Recent work has shown that over 80% of DIPG cases harbor the H3K27M mutation leading to global loss of the repressive H3K27… read more here.
Keywords: dipg targeting; targeting epigenetic; modifiers induce; induce immune ... See more keywords
Abstract 2907: Targeting the epigenetic regulator KAT2a in cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-2907
Abstract: Gene expression frequently requires the dynamic remodelling of the chromatin architecture to orchestrate the assembly of transcriptional protein complexes at the promoter sites of DNA. Chromatin remodelling complexes are multicomponent proteins that facilitate reorganisation of… read more here.
Keywords: targeting epigenetic; regulator kat2a; epigenetic regulator; gene expression ... See more keywords
Abstract 4900: Preclinical efficacy of targeting epigenetic mechanisms in AML with 3q26 lesions and EVI1 overexpression
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4900
Abstract: EVI1 gene is located at 3q26.2 in the MECOM locus and encodes for a zinc-finger transcription factor. Chromosome translocation t(3;3) or inv(3) at 3q26 repositions the enhancer (E) of the tumor suppressor GATA2 to induce… read more here.
Keywords: targeting epigenetic; evi1 overexpression; 3q26 lesions; lesions evi1 ... See more keywords
Targeting Epigenetic Mechanisms to Treat Alcohol Use Disorders (AUD).
Sign Up to like & getrecommendations! Published in 2021 at "Current pharmaceutical design"
DOI: 10.2174/1381612827666210203142539
Abstract: BACKGROUND The impact of abusive alcohol consumption on human health is remarkable. According to the World Health Organization (WHO), approximately 3.3 million people die annually because of harmful alcohol consumption (the figure represents around 5.9%… read more here.
Keywords: treat; targeting epigenetic; epigenetic mechanisms; alcohol ... See more keywords
Targeting Epigenetic Mechanisms: A Boon for Cancer Immunotherapy
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11010169
Abstract: Immunotherapy is rapidly emerging as a promising approach against cancer. In the last decade, various immunological mechanisms have been targeted to induce an increase in the immune response against cancer cells. However, despite promising results,… read more here.
Keywords: targeting epigenetic; immunotherapy; boon cancer; mechanisms boon ... See more keywords