Targeting epigenetics using synthetic lethality in precision medicine
Sign Up to like & getrecommendations! Published in 2018 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-018-2866-0
Abstract: Technological breakthroughs in genomics have had a significant impact on clinical therapy for human diseases, allowing us to use patient genetic differences to guide medical care. The “synthetic lethal approach” leverages on cancer-specific genetic rewiring… read more here.
Keywords: medicine; targeting epigenetics; epigenetics using; lethality precision ... See more keywords
Targeting Epigenetics in Cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Annual review of pharmacology and toxicology"
DOI: 10.1146/annurev-pharmtox-010716-105106
Abstract: Alterations of genes regulating epigenetic processes are frequently found as cancer drivers and may cause widespread alterations of DNA methylation, histone modification patterns, or chromatin structure that disrupt normal patterns of gene expression. Because of… read more here.
Keywords: targeting epigenetics; epigenetics cancer; pharmacology; cancer ... See more keywords
Antimalarial Inhibitors Targeting Epigenetics or Mitochondria in Plasmodium falciparum: Recent Survey upon Synthesis and Biological Evaluation of Potential Drugs against Malaria
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26185711
Abstract: Despite many efforts, malaria remains among the most problematic infectious diseases worldwide, mainly due to the development of drug resistance by P. falciparum. Over the past decade, new essential pathways have been emerged to fight… read more here.
Keywords: targeting epigenetics; epigenetics mitochondria; mitochondria plasmodium; plasmodium falciparum ... See more keywords