Targeting estrogen receptors in colorectal cancer
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DOI: 10.1007/s11033-020-05414-6
Abstract: Hormones have become a useful therapeutic aspect of clinical endocrinology but how to use them to optimize the health benefits and avoid adverse effects is a major challenge. Estrogen is an indispensable hormone for proper… read more here.
Keywords: receptors colorectal; colorectal cancer; estrogen; estrogen receptors ... See more keywords
Advances in targeting estrogen synthesis and receptors in patients with endometriosis
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2022.2152325
Abstract: ABSTRACT Introduction Endometriosis is an estrogen-dependent disease on the background of progesterone resistance. Increased estrogen production, low estrogen metabolization, and altered estrogen receptors (ERs) expression contribute to the hyperestrogenic milieu within endometriotic lesions. Since estrogens… read more here.
Keywords: estrogen; disease; synthesis receptors; advances targeting ... See more keywords
Combined Targeting of Estrogen Receptor Alpha and XPO1 Prevent Akt Activation, Remodel Metabolic Pathways and Induce Autophagy to Overcome Tamoxifen Resistance
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DOI: 10.3390/cancers11040479
Abstract: A majority of breast cancer specific deaths in women with ERĪ± (+) tumors occur due to metastases that are resistant to endocrine therapy. There is a critical need for novel therapeutic approaches to resensitize recurrent… read more here.
Keywords: akt; combined targeting; metabolic pathways; resistance ... See more keywords