Targeting ferroptosis in cardio‐metabolic‐diseases: Mechanisms and therapeutic prospects
Sign Up to like & getrecommendations! Published in 2023 at "Medicinal Research Reviews"
DOI: 10.1002/med.21934
Abstract: Cardio‐metabolic‐diseases (cardio‐metabolic‐diseases) are leading causes of death and disability worldwide and impose a tremendous burden on whole society as well as individuals. As a new type of regulated cell death (RCD), ferroptosis is distinct from… read more here.
Keywords: targeting ferroptosis; metabolic diseases; cardio metabolic;
Targeting ferroptosis contributes to ATPR-induced AML differentiation via ROS-autophagy-lysosomal pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Gene"
DOI: 10.1016/j.gene.2020.144889
Abstract: Ferroptosis, a newly discovered form of non-apoptotic cell death, is induced by an excessive degree of iron-dependent lipid peroxide. ATPR, a novel all-trans retinoic acid (ATRA) derivative, has been extensively developed to show superior anticancer… read more here.
Keywords: ferroptosis; differentiation; ferroptosis contributes; contributes atpr ... See more keywords
Melanin-Deferoxamine Nanoparticles Targeting Ferroptosis Mitigate Acute Kidney Injury via RONS Scavenging and Iron Ion Chelation.
Sign Up to like & getrecommendations! Published in 2024 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.4c14815
Abstract: Rhabdomyolysis (RM)-induced acute kidney injury (AKI) involves the release of large amounts of iron ions from excess myoglobin in the kidneys, which mediates the overproduction of reactive species with the onset of iron overload via… read more here.
Keywords: targeting ferroptosis; iron; ferroptosis; kidney injury ... See more keywords
Targeting ferroptosis: a promising approach for treating lung carcinoma
Sign Up to like & getrecommendations! Published in 2025 at "Cell Death Discovery"
DOI: 10.1038/s41420-025-02308-z
Abstract: Lung carcinoma incidence and fatality rates remain among the highest on a global scale. The efficacy of targeted therapies and immunotherapies is commonly compromised by the emergence of drug resistance and other factors, resulting in… read more here.
Keywords: targeting ferroptosis; lung; treatment lung; ferroptosis ... See more keywords
Targeting ferroptosis alleviates methionine‐choline deficient (MCD)‐diet induced NASH by suppressing liver lipotoxicity
Sign Up to like & getrecommendations! Published in 2020 at "Liver International"
DOI: 10.1111/liv.14428
Abstract: NASH is one of the fastest growing liver diseases that leads to severe steatosis, inflammation and ultimately liver injury. However, the pathophysiological mechanisms of NASH remain unclear and pharmacological treatment against the disease is unavailable… read more here.
Keywords: methionine choline; liver; ferroptosis; ferroptosis alleviates ... See more keywords
Targeting ferroptosis for leukemia therapy: exploring novel strategies from its mechanisms and role in leukemia based on nanotechnology
Sign Up to like & getrecommendations! Published in 2024 at "European Journal of Medical Research"
DOI: 10.1186/s40001-024-01822-7
Abstract: The latest findings in iron metabolism and the newly uncovered process of ferroptosis have paved the way for new potential strategies in anti-leukemia treatments. In the current project, we reviewed and summarized the current role… read more here.
Keywords: role leukemia; leukemia; nanotechnology; targeting ferroptosis ... See more keywords
Targeting ferroptosis as a promising therapeutic strategy to treat cardiomyopathy
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1146651
Abstract: Cardiomyopathies are a clinically heterogeneous group of cardiac diseases characterized by heart muscle damage, resulting in myocardium disorders, diminished cardiac function, heart failure, and even sudden cardiac death. The molecular mechanisms underlying the damage to… read more here.
Keywords: therapeutic strategy; cardiomyopathy; targeting ferroptosis; ferroptosis ... See more keywords
The metabolites from traditional Chinese medicine targeting ferroptosis for cancer therapy
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2024.1280779
Abstract: Cancer is a major disease with ever-increasing morbidity and mortality. The metabolites derived from traditional Chinese medicine (TCM) have played a significant role in combating cancers with curative efficacy and unique advantages. Ferroptosis, an iron-dependent… read more here.
Keywords: traditional chinese; cancer; targeting ferroptosis; medicine ... See more keywords
Targeting ferroptosis with natural products in stroke: therapeutic mechanisms and translational opportunities
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2025.1586345
Abstract: Ferroptosis is a new type of controlled cell death. It is distinguished by its reliance on iron and the production of lipid peroxidation. The role of ferroptosis in stroke has attracted a lot of attention… read more here.
Keywords: targeting ferroptosis; ferroptosis natural; natural products; ferroptosis ... See more keywords
Targeting Ferroptosis in Sensorineural Hearing Loss: A Mechanistic Review of Therapeutic Opportunities
Sign Up to like & getrecommendations! Published in 2025 at "Current Issues in Molecular Biology"
DOI: 10.3390/cimb47110876
Abstract: Ferroptosis, an iron-dependent form of regulated cell death, is emerging as a critical pathogenic mechanism and a highly promising therapeutic target in sensorineural hearing loss (SNHL). The irreversible loss of auditory hair cells, the hallmark… read more here.
Keywords: sensorineural hearing; loss; hearing loss; targeting ferroptosis ... See more keywords
Targeting Ferroptosis in Parkinson’s Disease: Mechanisms and Emerging Therapeutic Strategies
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms252313042
Abstract: Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra and the accumulation of α-synuclein in the brain. Ferroptosis, a recently identified form of regulated cell… read more here.
Keywords: ferroptosis; parkinson disease; ferroptosis parkinson; targeting ferroptosis ... See more keywords