Targeting ferroptosis in cardio‐metabolic‐diseases: Mechanisms and therapeutic prospects
Sign Up to like & getrecommendations! Published in 2023 at "Medicinal Research Reviews"
DOI: 10.1002/med.21934
Abstract: Cardio‐metabolic‐diseases (cardio‐metabolic‐diseases) are leading causes of death and disability worldwide and impose a tremendous burden on whole society as well as individuals. As a new type of regulated cell death (RCD), ferroptosis is distinct from… read more here.
Keywords: targeting ferroptosis; metabolic diseases; cardio metabolic;
Targeting ferroptosis contributes to ATPR-induced AML differentiation via ROS-autophagy-lysosomal pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Gene"
DOI: 10.1016/j.gene.2020.144889
Abstract: Ferroptosis, a newly discovered form of non-apoptotic cell death, is induced by an excessive degree of iron-dependent lipid peroxide. ATPR, a novel all-trans retinoic acid (ATRA) derivative, has been extensively developed to show superior anticancer… read more here.
Keywords: ferroptosis; differentiation; ferroptosis contributes; contributes atpr ... See more keywords
Targeting ferroptosis alleviates methionine‐choline deficient (MCD)‐diet induced NASH by suppressing liver lipotoxicity
Sign Up to like & getrecommendations! Published in 2020 at "Liver International"
DOI: 10.1111/liv.14428
Abstract: NASH is one of the fastest growing liver diseases that leads to severe steatosis, inflammation and ultimately liver injury. However, the pathophysiological mechanisms of NASH remain unclear and pharmacological treatment against the disease is unavailable… read more here.
Keywords: methionine choline; liver; ferroptosis; ferroptosis alleviates ... See more keywords
Targeting ferroptosis as a promising therapeutic strategy to treat cardiomyopathy
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1146651
Abstract: Cardiomyopathies are a clinically heterogeneous group of cardiac diseases characterized by heart muscle damage, resulting in myocardium disorders, diminished cardiac function, heart failure, and even sudden cardiac death. The molecular mechanisms underlying the damage to… read more here.
Keywords: therapeutic strategy; cardiomyopathy; targeting ferroptosis; ferroptosis ... See more keywords
Targeting Ferroptosis in Colorectal Cancer
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DOI: 10.3390/metabo12080745
Abstract: Ferroptosis is a unique way of regulating cell death (RCD), which is quite different from other programmed cell deaths such as autophagy. It presents iron overload, accumulation of reactive oxygen species (ROS), and lipid peroxidation.… read more here.
Keywords: cell; targeting ferroptosis; colorectal cancer; tumor ... See more keywords
Phytochemicals Targeting Ferroptosis: Therapeutic Opportunities and Prospects for Treating Breast Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15111360
Abstract: Ferroptosis, a recently discovered iron-dependent regulated cell death, has been implicated in the therapeutic responses of various cancers including breast cancer, making it a promising therapeutic target to manage this malignancy. Phytochemicals are conventional sources… read more here.
Keywords: breast cancer; targeting ferroptosis; cancer; phytochemicals targeting ... See more keywords
Targeting Ferroptosis as a Novel Approach to Alleviate Aortic Dissection
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.72528
Abstract: A variety of programmed cell death types have been shown to participate in the loss of smooth muscle cells (SMCs) during the development of aortic dissection (AD), but it is still largely unclear whether ferroptosis… read more here.
Keywords: aortic dissection; slc7a11 fsp1; targeting ferroptosis; mettl3 ... See more keywords