Targeting fibroblast CD248 attenuates CCL17-expressing macrophages and tissue fibrosis
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-73194-x
Abstract: The role of fibroblasts in tissue fibrosis has been extensively studied. Activated fibroblasts, namely myofibroblasts, produce pathological extracellular matrix. CD248, a type I transmembrane glycoprotein, is expressed in fibroblasts after birth. In human chronic kidney… read more here.
Keywords: cd248 mice; fibrosis; cd248; tissue fibrosis ... See more keywords
Targeting Fibroblast Growth Factor Receptor Pathway: Precision Medicine for Biliary Cancer and Beyond
Sign Up to like & getrecommendations! Published in 2023 at "Seminars in Liver Disease"
DOI: 10.1055/a-2049-3149
Abstract: FGFR2 Inhibitors are now being included in the treatment guidelines of multiple countries for patients with advanced cholangiocarcinoma (CCA). Activation of the FGF-FGFR pathway is related to proliferation and tumor progression. Targeting the FGF-FGFR pathway… read more here.
Keywords: medicine; receptor pathway; factor receptor; targeting fibroblast ... See more keywords