Targeting fibroblast CD248 attenuates CCL17-expressing macrophages and tissue fibrosis
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-73194-x
Abstract: The role of fibroblasts in tissue fibrosis has been extensively studied. Activated fibroblasts, namely myofibroblasts, produce pathological extracellular matrix. CD248, a type I transmembrane glycoprotein, is expressed in fibroblasts after birth. In human chronic kidney… read more here.
Keywords: cd248 mice; fibrosis; cd248; tissue fibrosis ... See more keywords
Targeting Fibroblast Growth Factor Receptor Pathway: Precision Medicine for Biliary Cancer and Beyond
Sign Up to like & getrecommendations! Published in 2023 at "Seminars in Liver Disease"
DOI: 10.1055/a-2049-3149
Abstract: FGFR2 Inhibitors are now being included in the treatment guidelines of multiple countries for patients with advanced cholangiocarcinoma (CCA). Activation of the FGF-FGFR pathway is related to proliferation and tumor progression. Targeting the FGF-FGFR pathway… read more here.
Keywords: medicine; receptor pathway; factor receptor; targeting fibroblast ... See more keywords
Targeting fibroblast phenotype switching in cardiac remodelling as a promising antifibrotic strategy.
Sign Up to like & getrecommendations! Published in 2024 at "European heart journal"
DOI: 10.1093/eurheartj/ehae722
Abstract: Myocardial fibrosis, a common feature of heart disease, remains an unsolved clinical challenge. Fibrosis resolution requires activation of cardiac fibroblasts exhibiting context-dependent beneficial and detrimental dichotomy. Here, we explored the hypothesis of fibroblast reversible transition… read more here.
Keywords: cardiac remodelling; phenotype switching; fibrosis; fibroblast phenotype ... See more keywords