Integrated Mendelian randomization and single-cell RNA-sequencing analyses identified OAS1 as a novel therapeutic target for erectile dysfunction via targeting fibroblasts
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DOI: 10.1186/s13062-024-00587-7
Abstract: Clinically, phosphodiesterase type 5 inhibitors (PDE5-Is) remain the first-line therapy for erectile dysfunction (ED) patients; however, approximately 35% of these patients are still failing to respond to the therapeutic effects. So, urgent needs are required… read more here.
Keywords: single cell; targeting fibroblasts; via targeting; erectile dysfunction ... See more keywords
Targeting fibroblasts in pathological bone formation: mechanisms and treatments
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DOI: 10.3389/fcell.2025.1612950
Abstract: Fibroblasts are integral to the pathological processes underlying abnormal bone formation, including heterotopic ossification (HO), ankylosing spondylitis (AS), and ossification of the posterior longitudinal ligament (OPLL). This review summarized the diverse roles of fibroblasts, from… read more here.
Keywords: targeting fibroblasts; bone formation; formation; fibroblasts pathological ... See more keywords
Highlights of Strategies Targeting Fibroblasts for Novel Therapies for Rheumatoid Arthritis
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DOI: 10.3389/fmed.2022.846300
Abstract: Synovial fibroblasts of rheumatoid arthritis (RA) play a critical role in perpetuation of chronic inflammation by interaction with immune and inflammatory cells and in cartilage and bone invasion, but current therapies for RA are not… read more here.
Keywords: fibroblast targeted; rheumatoid arthritis; fibroblast; strategies targeting ... See more keywords