Targeting FoxO transcription factors with HDAC inhibitors for the treatment of osteoarthritis
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DOI: 10.1136/ard-2021-221269
Abstract: Objectives Osteoarthritis (OA) features ageing-related defects in cellular homeostasis mechanisms in articular cartilage. These defects are associated with suppression of forkhead box O (FoxO) transcription factors. FoxO1 or FoxO3 deficient mice show early onset OA… read more here.
Keywords: expression; factors hdac; transcription factors; foxo transcription ... See more keywords