Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109957
Abstract: The highly lethal brain cancer glioblastoma (GBM) poses a daunting challenge because the blood-brain barrier renders potentially druggable amplified or mutated oncoproteins relatively inaccessible. Here, we identify sphingomyelin phosphodiesterase 1 (SMPD1), an enzyme that regulates… read more here.
Keywords: brain penetrant; targeting glioblastoma; drug; brain ... See more keywords
Targeting glioblastoma stem-cells: a recurrent challenge in neurooncology
Sign Up to like & getrecommendations! Published in 2017 at "Translational cancer research"
DOI: 10.21037/16225
Abstract: Glioblastoma (GBM) is the most common and most aggressive primary brain tumor in adults. To date, this tumor remains rapidly fatal despite treatment, median overall survival not exceeding 15 months from diagnosis (1). read more here.
Keywords: recurrent challenge; targeting glioblastoma; cells recurrent; challenge neurooncology ... See more keywords