Targeting GLP-1 receptor trafficking to improve agonist efficacy
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DOI: 10.1038/s41467-018-03941-2
Abstract: Glucagon-like peptide-1 receptor (GLP-1R) activation promotes insulin secretion from pancreatic beta cells, causes weight loss, and is an important pharmacological target in type 2 diabetes (T2D). Like other G protein-coupled receptors, the GLP-1R undergoes agonist-mediated endocytosis,… read more here.
Keywords: agonist; targeting glp; efficacy; receptor trafficking ... See more keywords