Targeting Glutamine Metabolism and PD-L1: A Novel Anti-tumor Pas de Deux.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular cell"
DOI: 10.1016/j.molcel.2020.11.005
Abstract: In this issue of Molecular Cell, Byun et al. (2020) find that the dual targeting of glutamine metabolism and the PD-L1 checkpoint inhibitor augments anti-tumor immunity. Mechanistically, decreased glutamine availability attenuated S-glutathionylation of SERCA, resulting in… read more here.
Keywords: glutamine metabolism; anti tumor; targeting glutamine; metabolism novel ... See more keywords
Zeolitic imidazolate framework-based nanoparticles for the cascade enhancement of cancer chemodynamic therapy by targeting glutamine metabolism.
Sign Up to like & getrecommendations! Published in 2022 at "Nanoscale"
DOI: 10.1039/d2nr01736a
Abstract: The reprogrammed amino acid metabolism maintains the powerful antioxidant defense and DNA damage repair capacity of cancer cells, which could promote their escape from reactive oxygen species (ROS)-induced damage and inevitably diminish the efficacy of… read more here.
Keywords: metabolism; glutamine metabolism; zeolitic imidazolate; chemodynamic therapy ... See more keywords
Advancing Cancer Treatment by Targeting Glutamine Metabolism—A Roadmap
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14030553
Abstract: Simple Summary Dysregulated glutamine metabolism is one of the metabolic features evident in cancer cells when compared to normal cells. Cancer cells utilize glutamine for energy generation as well as the synthesis of other molecules… read more here.
Keywords: metabolism; glutamine metabolism; treatment; targeting glutamine ... See more keywords